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    CG15445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15445provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031161
    Locus tag
    Dmel_CG15445
    See related
    AllianceGenome:FB:FBgn0031161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15445; NUB1
    Summary
    Predicted to be involved in regulation of ubiquitin-dependent protein catabolic process. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15445 in Genome Data Viewer
    Location:
    19F1-19F1; 1-65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21117159..21120444)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20988186..20991471)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stargazin-like protein Neighboring gene uncharacterized protein Neighboring gene uncoordinated Neighboring gene antisense RNA:CR44374 Neighboring gene lipid droplet defective Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
    2. Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance. Lu B, et al. Nat Neurosci, 2013 May. PMID 23525043
    3. High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Zhu JY, et al. Elife, 2017 Jan 20. PMID 28084990, Free PMC Article
    4. Systematic analysis of the visual projection neurons of Drosophila melanogaster. I. Lobula-specific pathways. Otsuna H, et al. J Comp Neurol, 2006 Aug 20. PMID 16802334
    5. RNAseq analysis of the drug jian-yan-ling (JYL) using both in vivo and in vitro models. Zhang X, et al. Heliyon, 2023 May. PMID 37251843, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in regulation of ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15445-PA
    CG15445-PE
    CG15445-PF
    CG15445-PG
    CG15445-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21117159..21120444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167729.2 → NP_728390.1  uncharacterized protein Dmel_CG15445, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU53, Q7KU54, Q8IQ39, Q9VRF3
      Related
      FBpp0076942
      Conserved Domains (2) summary
      cd14291
      Location:354 → 391
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:484 → 519
      UBA_like_SF; UBA domain-like superfamily

    2. NM_001272827.1 → NP_001259756.1  uncharacterized protein Dmel_CG15445, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU53, Q7KU54, Q8IQ39, Q9VRF3
      Conserved Domains (2) summary
      cd14291
      Location:354 → 391
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:484 → 519
      UBA_like_SF; UBA domain-like superfamily

    3. NM_134592.4 → NP_608436.4  uncharacterized protein Dmel_CG15445, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608436.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU53, Q7KU54, Q8IQ39, Q9VRF3
      Conserved Domains (2) summary
      cd14291
      Location:354 → 391
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:484 → 519
      UBA_like_SF; UBA domain-like superfamily

    4. NM_167730.2 → NP_728391.3  uncharacterized protein Dmel_CG15445, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728391.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU53, Q7KU54, Q8IQ39, Q9VRF3
      Conserved Domains (2) summary
      cd14291
      Location:354 → 391
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:484 → 519
      UBA_like_SF; UBA domain-like superfamily

    5. NM_167731.2 → NP_728392.2  uncharacterized protein Dmel_CG15445, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728392.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU53, Q7KU54, Q8IQ39, Q9VRF3
      Conserved Domains (2) summary
      cd14291
      Location:354 → 391
      UBA1_NUB1_like; UBA1 domain found in NEDD8 ultimate buster 1 (NUB1) and similar proteins
      cl21463
      Location:484 → 519
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRF3 Q9VRF3

    Gene LinkOut

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