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    her hermaphrodite [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    herprovided by FlyBase
    Official Full Name
    hermaphroditeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001185
    Locus tag
    Dmel_CG4694
    See related
    AllianceGenome:FB:FBgn0001185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4694; Dmel\CG4694; FBgn 1185; l(2)mat
    Summary
    Predicted to enable DNA binding activity. Involved in sex determination. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See her in Genome Data Viewer
    Location:
    36A10-36A10; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16677185..16679691)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16677185..16679691)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene miles to go Neighboring gene long non-coding RNA:CR44151 Neighboring gene Transient receptor potential cation channel gamma Neighboring gene mir-2497 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene squash Neighboring gene grapes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Maternal Inheritance of a Sex-Limited Lethal Effect in DROSOPHILA MELANOGASTER. Redfield H. Genetics, 1926 Sep. PMID 17246468, Free PMC Article
    2. A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila melanogaster. Pultz MA, et al. Genetics, 1994 Jan. PMID 8138157, Free PMC Article
    3. Sex determination and dosage compensation in Drosophila melanogaster. Baker BS, et al. Annu Rev Genet, 1983. PMID 6421227
    4. hermaphrodite and doublesex function both dependently and independently to control various aspects of sexual differentiation in Drosophila. Li H, et al. Development, 1998 Jul. PMID 9636079
    5. The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy. Pultz MA, et al. Development, 1995 Jan. PMID 7867511

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female somatic sex determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination, primary response to X:A ratio TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hermaphrodite
    Names
    CG4694-PA
    CG4694-PB
    her-PA
    her-PB
    lethal (2) maternal
    lethal(2)maternal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16677185..16679691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273577.1 → NP_001260506.1  hermaphrodite, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61373, Q9VJJ6
      Conserved Domains (3) summary
      PRK09510
      Location:140 → 220
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      sd00017
      Location:23 → 45
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:132 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_057224.5 → NP_476572.1  hermaphrodite, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61373, Q9VJJ6
      Related
      FBpp0080440
      Conserved Domains (3) summary
      PRK09510
      Location:140 → 220
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      sd00017
      Location:23 → 45
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:132 → 149
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61373 O61373
    Q9VJJ6 Q9VJJ6

    Gene LinkOut

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