sqh spaghetti squash [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sqhprovided by FlyBase
Official Full Name: spaghetti squashprovided by FlyBase
Primary source: FLYBASE:FBgn0003514
Locus tag: Dmel_CG3595
See related: AllianceGenome:FB:FBgn0003514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: actomyosin; CG3595; Dmel\CG3595; DmMRLC_C; MLC; MLRC; MRLC; Myo; myo II; Myo II; myo-II; Myo-II; Myo-II RLC; myoII; MyoII; myosin; myosin 2; myosin II; Myosin II; NMM; pMyo-II; RLC; RLC2; RMLC; sgh; spg; Sqh; squ; ssq
Summary: Enables ATPase activator activity and myosin heavy chain binding activity. Involved in several processes, including compartment pattern specification; imaginal disc-derived wing morphogenesis; and oogenesis. Located in several cellular components, including apicomedial cortex; cellularization cleavage furrow invagination front; and cytoskeleton. Part of myosin II complex. Colocalizes with adherens junction and perinuclear region of cytoplasm. Is expressed in several structures, including adult dorsal vessel; adult head; epidermis; epithelial cell; and gut section. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to several human genes including MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5E1-5E1; 1-16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6223061..6225140, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6117094..6119173, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos.
Title: DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos.
Here, the authors show that the sole type I phosphatidylinositol transfer protein, Vibrator, controls asymmetric division of Drosophilaneural stem cells (NSCs) by physically anchoring myosin II regulatory light chain, Sqh, to the NSC cortex.
Title: Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.
inclusion body myopathy type 3 disease state in heterozygote Drosophila was examined in order to gain a mechanistic understanding of myosin E701K pathogenicity.
Title: A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects.
Computer simulation coupled with laser ablation suggests that Dunk-dependent maintenance of cortical myosin enables mechanical tension build-up, thereby providing a mechanism to guide myosin flow and define the hexagonal symmetry of the furrows.
Title: Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity.
mechanical forces regulate myosin dynamics during embryonic wound repair.
Title: Tension regulates myosin dynamics during Drosophila embryonic wound repair.
the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration.
Title: Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling.
Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis
Title: Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis.
evidence for mechanosensitivity of cell-cell junctions and implications that myosin-mediated tension can prevent Snail-driven Eepithelial-mesenchymal transitions
Title: Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.
Study indicated that Sqh is crucial to regulate the stability of the transcription factor Cubitus interruptus (Ci) in Hedgehog (Hh) pathway.
Title: Sqh is involved in the regulation of Ci stability in Hh signaling pathway.
flw is a key regulator of basal myosin oscillations and cell contractions underlying egg chamber elongation.
Title: Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament-based movement	IC Inferred by Curator more info	PubMed
involved_in apical constriction	TAS Traceable Author Statement more info	PubMed
involved_in apical constriction involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell elongation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compartment boundary maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of a compartment boundary	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing hair organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myosin II filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear axial expansion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial embryo cellularization	IEP Inferred from Expression Pattern more info	PubMed
involved_in tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in actomyosin contractile ring actin filament	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cellularization cleavage furrow invagination front	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in female germline ring canal inner rim	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IPI Inferred from Physical Interaction more info	PubMed
colocalizes_with perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spaghetti squash

Names: CG3595-PA; CG3595-PB; CG3595-PC; CG3595-PD; CG3595-PE; Myo-II regulatory light chain; MyoII; MyoII regulatory light chain; Myosin-II; Myosin-II light chain; Spaghetti-Squash; actomyosin; light chain of nonmuscle myosin II; myosin; myosin 2; myosin II; myosin II RLC; myosin II regulatory light chain; myosin II regulatory subunit; myosin LC; myosin light chain; myosin regulatory light chain; myosinII; non-muscle myosin II; non-muscle myosin II regulatory light chain; non-muscle myosin-II; nonmuscle MyoII; nonmuscle myosin II; nonmuscle myosin II regulatory light chain; phospho-Myosin light chain 2; regulatory light chain; regulatory light chain of myosin; regulatory light chain of myosin II; regulatory light chain of nonmuscle myosin II; regulatory light chain of nonmuscle myosin-II; regulatory myosin light chain; sqh-PA; sqh-PB; sqh-PC; sqh-PD; sqh-PE; squash; type II myosin regulatory light chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6223061..6225140 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078502.3 → NP_511057.1 spaghetti squash, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511057.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40423, Q540V2, Q9W428

UniProtKB/TrEMBL

F6J1D0

Related

FBpp0070842

Conserved Domains (1) summary

COG5126
Location:15 → 170

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001298001.1 → NP_001284930.1 spaghetti squash, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284930.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40423, Q540V2, Q9W428

UniProtKB/TrEMBL

F6J1D0

Conserved Domains (1) summary

COG5126
Location:15 → 170

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001298000.1 → NP_001284929.1 spaghetti squash, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284929.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40423, Q540V2, Q9W428

UniProtKB/TrEMBL

F6J1D0

Conserved Domains (1) summary

COG5126
Location:15 → 170

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001297999.1 → NP_001284928.1 spaghetti squash, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40423, Q540V2, Q9W428

UniProtKB/TrEMBL

F6J1D0

Conserved Domains (1) summary

COG5126
Location:15 → 170

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001298002.1 → NP_001284931.1 spaghetti squash, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284931.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40423, Q540V2, Q9W428

UniProtKB/TrEMBL

F6J1D0

Conserved Domains (1) summary

COG5126
Location:15 → 170

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]