Grip84 Gamma-tubulin ring protein 84 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Grip84provided by FlyBase
Official Full Name: Gamma-tubulin ring protein 84provided by FlyBase
Primary source: FLYBASE:FBgn0026430
Locus tag: Dmel_CG3917
See related: AllianceGenome:FB:FBgn0026430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3917; Dgrip84; DGrip84; Dgrips84; Dmel\CG3917; GCP2; grip84; l(1)[[t]]PG36; l(1)[[t]]PG66
Summary: Enables gamma-tubulin binding activity. Contributes to microtubule minus-end binding activity. Involved in several processes, including meiotic cell cycle; microtubule cytoskeleton organization; and spermatogenesis. Part of gamma-tubulin ring complex and gamma-tubulin small complex. Colocalizes with centrosome and mitotic spindle. Is expressed in several structures, including adult head; antennal primordium; central brain primordium; head epidermis primordium; and ventral nerve cord primordium. Used to study pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D1-18D1; 1-63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19559431..19565764, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19453464..19459797, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This indicates a role for Dgrip84 in regulating the activity and/or the location of the gamma-tubulin complexes formed with gammaTub37CD and gammaTub23C.
Title: Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila.
Dgrip84 is required in some aspects of microtubule dynamics and organization both in interphase and mitosis
Title: The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.
findings showed that the molecular requirements for a functional spindle checkpoint included components of the large gamma-tubulin ring complex; however, their localization at the centrosome and centrosome integrity were not essential for this function
Title: A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
contributes_to microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to microtubule minus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle-templated microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin ring complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin small complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin small complex	IPI Inferred from Physical Interaction more info	PubMed
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
colocalizes_with mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Gamma-tubulin ring protein 84

Names: CG3917-PA; CG3917-PB; CG3917-PC; CG3917-PD; CG3917-PE; CG3917-PF; DGrip84; Grip84-PA; Grip84-PB; Grip84-PC; Grip84-PD; Grip84-PE; Grip84-PF; gamma-tubulin ring protein 84

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19559431..19565764 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298515.1 → NP_001285444.1 Gamma-tubulin ring protein 84, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285444.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIB1, X2JG40

Conserved Domains (1) summary

pfam04130
Location:204 → 721

Spc97_Spc98; Spc97 / Spc98 family
NM_001169327.2 → NP_001162798.1 Gamma-tubulin ring protein 84, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162798.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJQ3, Q5BIB1

Conserved Domains (1) summary

pfam04130
Location:278 → 795

Spc97_Spc98; Spc97 / Spc98 family
NM_167662.2 → NP_728264.1 Gamma-tubulin ring protein 84, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728264.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIB1, Q8IQW7

Related

FBpp0074544

Conserved Domains (1) summary

pfam04130
Location:278 → 795

Spc97_Spc98; Spc97 / Spc98 family
NM_001169326.2 → NP_001162797.1 Gamma-tubulin ring protein 84, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162797.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJQ4, Q5BIB1

Conserved Domains (1) summary

pfam04130
Location:278 → 795

Spc97_Spc98; Spc97 / Spc98 family
NM_078685.3 → NP_523409.1 Gamma-tubulin ring protein 84, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523409.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIB1, X2JG40

Related

FBpp0074546

Conserved Domains (1) summary

pfam04130
Location:204 → 721

Spc97_Spc98; Spc97 / Spc98 family
NM_167663.2 → NP_728265.1 Gamma-tubulin ring protein 84, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728265.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95RT7, Q9XYP7

UniProtKB/TrEMBL

Q5BIB1

Related

FBpp0074545

Conserved Domains (1) summary

pfam04130
Location:204 → 721

Spc97_Spc98; Spc97 / Spc98 family