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    Charon charon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Charonprovided by FlyBase
    Official Full Name
    charonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031317
    Locus tag
    Dmel_CG5118
    See related
    AllianceGenome:FB:FBgn0031317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.11; CG5118; Dmel\CG5118; pickle
    Summary
    Enables several functions, including DNA-binding transcription activator activity; DNA-binding transcription repressor activity; and NF-kappaB binding activity. Involved in defense response to other organism; regulation of DNA-templated transcription; and regulation of peptidoglycan recognition protein signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Charon in Genome Data Viewer
    Location:
    21F2-21F2; 2-2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1170753..1172805, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1170753..1172805, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Integrator 14 Neighboring gene uncharacterized protein Neighboring gene Phospholipase A2 activator protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Charon Mediates Immune Deficiency-Driven PARP-1-Dependent Immune Responses in Drosophila. Ji Y, et al. J Immunol, 2016 Sep 15. PMID 27527593, Free PMC Article
    2. Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior. Chandler JA, et al. iScience, 2022 Apr 15. PMID 35313693, Free PMC Article
    3. Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense. Morris O, et al. Cell Host Microbe, 2016 Sep 14. PMID 27631699, Free PMC Article
    4. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Goto A, et al. Immunity, 2018 Aug 21. PMID 30119996, Free PMC Article
    5. NF-κB disinhibition contributes to dendrite defects in fly models of neurodegenerative diseases. Han MH, et al. J Cell Biol, 2020 Dec 7. PMID 33090185, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    charon
    Names
    CG5118-PA
    Charon-PA
    pickle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1170753..1172805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134737.4 → NP_608581.2  charon [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608581.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRJ4, Q9VPY3
      Related
      FBpp0077644
      Conserved Domains (4) summary
      COG0666
      Location:216 → 400
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:300 → 394
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:340 → 488
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:335 → 369
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPY3 Q9VPY3

    Gene LinkOut

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