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    ICA69 Islet cell autoantigen 69 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ICA69provided by FlyBase
    Official Full Name
    Islet cell autoantigen 69 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037050
    Locus tag
    Dmel_CG10566
    See related
    AllianceGenome:FB:FBgn0037050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10566; dCG10566-PA; Dm ric-19; Dmel\CG10566; ICA-69
    Summary
    Predicted to enable protein domain specific binding activity. Involved in glutamate receptor clustering; membrane bending; and postsynapse organization. Located in postsynapse of neuromuscular junction. Is expressed in embryonic brain; embryonic/larval neuromuscular junction; larval nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1) and ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ICA69 in Genome Data Viewer
    Location:
    78B2-78B2; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21131446..21133310)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21124546..21126410)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase 78C Neighboring gene Asparagine synthetase Neighboring gene chromosome bows

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Bin/Amphiphysin/Rvs (BAR) family proteins may assemble on the same tubule to regulate membrane organization in vivo. Mallik B, et al. Heliyon, 2024 Jul 15. PMID 39040266, Free PMC Article
    2. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. Holst B, et al. PLoS Biol, 2013. PMID 23630454, Free PMC Article
    3. The BAR-domain family of proteins: a case of bending and binding? Habermann B. EMBO Rep, 2004 Mar. PMID 14993925, Free PMC Article
    4. Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila. Mallik B, et al. Development, 2017 Jun 1. PMID 28455372
    5. Functional tests of enhancer conservation between distantly related species. Ruvinsky I, et al. Development, 2003 Nov. PMID 12944426

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ICA69 regulates NMJ organization through a pathway that involves PICK1 and Rab2.
      Title: Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynapse of neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    islet cell autoantigen 69 kDa
    Names
    CG10566-PA
    CG10566-PB
    ICA69-PA
    ICA69-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21131446..21133310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141026.2 → NP_649283.1  islet cell autoantigen 69 kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP78
      Related
      FBpp0077950
      Conserved Domains (2) summary
      cd07661
      Location:33 → 235
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:345 → 396
      ICA69; Islet cell autoantigen ICA69, C-terminal domain

    2. NM_001259926.1 → NP_001246855.1  islet cell autoantigen 69 kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP78
      Conserved Domains (2) summary
      cd07661
      Location:33 → 235
      BAR_ICA69; The Bin/Amphiphysin/Rvs (BAR) domain of Islet Cell Autoantigen 69-kDa
      pfam04629
      Location:345 → 396
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP78 Q9VP78

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