spin spinster [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spinprovided by FlyBase
Official Full Name: spinsterprovided by FlyBase
Primary source: FLYBASE:FBgn0086676
Locus tag: Dmel_CG8428
See related: AllianceGenome:FB:FBgn0086676
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 25/11; bnch; CG8428; Dmel\CG8428; l(2)10403; l(2)k02511; l(2)k09905; l(2)W5; l(2R)W5; Spin
Summary: Predicted to enable transmembrane transporter activity. Involved in several processes, including negative regulation of BMP signaling pathway; nervous system development; and nurse cell apoptotic process. Located in late endosome membrane. Is expressed in several structures, including adult brain; adult head; adult heart; adult pars intercerebralis; and subperineurial glial cell. Used to study neuronal ceroid lipofuscinosis and sphingolipidosis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to several human genes including SPNS1 (SPNS lysolipid transporter 1, lysophospholipid). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52E6-52E7; 2-77 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16124981..16138238)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12012486..12025743)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Within the migrating perineurial glial cells, Spinster is required to downregulate Decapentaplegic signaling activity, which ceases migratory abilities. Also, Spinster affects the growth of the carpet cell, which indirectly modulates glial migration.
Title: Spinster controls Dpp signaling during glial migration in the Drosophila eye.
Spinster (Spin) encodes a putative lysosomal efflux permease with the hallmarks of a sugar transporter. Spin mutants accumulate lysosomal carbohydrates and enlarged lysosomes.
Title: Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation.
spin promotes cell death mechanisms that are regulated negatively by th and emc and positively by atg8a
Title: Phenotypic interactions of spinster with the genes encoding proteins for cell death control in Drosophila melanogaster.
Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
Title: Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis.
Spin is expressed in nerve and muscle and is required for normal synaptic growth. Spin is found in a late endosomal compartment;there is evidence for altered endosomal/lysosomal function in Spin-deficient flies.
Title: Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0356 (e-PCR)
- UniSTS:79975

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in courtship behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval central nervous system remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISM Inferred from Sequence Model more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spinster

Names: CG8428-PA; CG8428-PB; CG8428-PC; CG8428-PD; CG8428-PE; Spinster/Benchwarmer; benchwarmer; diphthong; lethal (2) W5; spin-PA; spin-PB; spin-PC; spin-PD; spin-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16124981..16138238

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166146.2 → NP_725532.1 spinster, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725532.1

Status: REVIEWED

UniProtKB/TrEMBL

K4M4D5

Related

FBpp0088551

Conserved Domains (2) summary

cd06174
Location:117 → 489

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:120 → 462

MFS_1; Major Facilitator Superfamily
NM_166144.2 → NP_725530.1 spinster, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725530.1

Status: REVIEWED

UniProtKB/TrEMBL

K4M4D5

Related

FBpp0088550

Conserved Domains (2) summary

cd06174
Location:117 → 489

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:120 → 462

MFS_1; Major Facilitator Superfamily
NM_080084.3 → NP_524823.1 spinster, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524823.1

Status: REVIEWED

UniProtKB/TrEMBL

K4M4D5

Related

FBpp0088549

Conserved Domains (2) summary

cd06174
Location:117 → 489

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:120 → 462

MFS_1; Major Facilitator Superfamily
NM_166147.2 → NP_725533.1 spinster, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725533.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GQQ0

Related

FBpp0088548

Conserved Domains (2) summary

cd06174
Location:117 → 290

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:120 → 347

MFS_1; Major Facilitator Superfamily
NM_166145.2 → NP_725531.1 spinster, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725531.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZAA4, Q960X6, Q9GQP9, Q9GQQ0, Q9GQQ1, Q9GQQ2, Q9GQQ3, Q9V7J3

UniProtKB/TrEMBL

K4M4D5, R4NR58

Related

FBpp0088552

Conserved Domains (2) summary

cd06174
Location:117 → 489

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:120 → 462

MFS_1; Major Facilitator Superfamily