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    CG7025 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7025provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031930
    Locus tag
    Dmel_CG7025
    See related
    AllianceGenome:FB:FBgn0031930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7025
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7025 in Genome Data Viewer
    Location:
    28C1-28C1; 2-28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7691109..7692683, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7691109..7692683, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Myosin 28B1 Neighboring gene long non-coding RNA:CR44148 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Thioester-containing protein 2 Neighboring gene antisense RNA:CR44990 Neighboring gene Thioester-containing protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
    2. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
    3. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article
    4. Transcriptional signatures in response to wheat germ agglutinin and starvation in Drosophila melanogaster larval midgut. Li HM, et al. Insect Mol Biol, 2009 Feb. PMID 19196346
    5. Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling. Erkosar B, et al. PLoS One, 2014. PMID 24733183, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7025-PA
    NP_609133.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7691109..7692683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135289.3 → NP_609133.2  uncharacterized protein Dmel_CG7025 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609133.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BI80, Q9VLZ1
      Conserved Domains (2) summary
      cd03860
      Location:123 → 416
      M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
      pfam02244
      Location:36 → 103
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BI80 Q5BI80
    Q9VLZ1 Q9VLZ1

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