dac dachshund [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dacprovided by FlyBase
Official Full Name: dachshundprovided by FlyBase
Primary source: FLYBASE:FBgn0005677
Locus tag: Dmel_CG4952
See related: AllianceGenome:FB:FBgn0005677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS02780.3; CG4952; Dac; DAC; Dac2-3; dach; Dach; Dachshund; Dm-DAC; Dmel\CG4952; l(2)36Ae; l(2)rK364; spn
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including antennal joint development; genital disc sexually dimorphic development; and nervous system development. Located in nucleus. Is expressed in several structures, including eye photoreceptor cell; head epidermis primordium; imaginal disc; intrinsic neurons; and organism subdivision. Orthologous to several human genes including DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36A1-36A2; 2-52 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16466512..16485998, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16466512..16485998, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dac is part of an essential positive feedback loop in the Hh pathway, guaranteeing the speed and the accuracy of Drosophila retinogenesis.
Title: dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis.
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex
Title: The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex.
Sex-specific repression of dachshund is required for Drosophila sex comb development.
Title: Sex-specific repression of dachshund is required for Drosophila sex comb development.
Evolution of sex comb from the primitive bristle pattern in Drosophila is associated with modification in the developmental regulatory protein Dachshund.
Title: Evolution of sex comb from the primitive bristle pattern in Drosophila is associated with modification in the developmental regulatory protein Dachshund.
mammalian homolog of Dac, Dach1/2, facilitated the action of Pax6 on expression of islet hormone genes in cultured mammalian cells. These observations indicate the conserved role of Dac/Dach in controlling insulin expression in conjunction with Ey/Pax6
Title: Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression.
The high activates and represses dachshund (dac) in the distal cells of the leg disc, while intermediate [Wg+Dpp] activates dac in medial tissue.
Title: Establishment of medial fates along the proximodistal axis of the Drosophila leg through direct activation of dachshund by Distalless.
two eye enhancers act redundantly and in concert with each other to integrate distinct upstream inputs and direct the eye-specific expression of dac
Title: Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund.
dachshund has a role in regulating development of the embryonic head and eye of Drosophila
Title: Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila.
The fly dachshund gene is related to the Ski proto-oncogene and is expressed in eye and limb. In Drosophila eye development, dachshund is a component of an interacting network of proteins.
Title: Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.
only DD1 domain is essential for Dac function and it plays a central role for nuclear localization of Dac.
Title: Structure-function analysis of the Drosophila retinal determination protein Dachshund.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2075 (e-PCR)
- UniSTS:48314

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in antennal joint development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc development	TAS Traceable Author Statement more info	PubMed
involved_in genital disc morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed
involved_in mushroom body development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermathecum morphogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dachshund

Names: CG4952-PA; CG4952-PB; CG4952-PC; CG4952-PD; CG4952-PF; CG4952-PG; dac-PA; dac-PB; dac-PC; dac-PD; dac-PF; dac-PG; dachsund; dacshund; daschund; spinosus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16466512..16485998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014486.3 → NP_001014486.1 dachshund, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014486.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24029, Q59DZ0

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family
NM_165159.3 → NP_723968.1 dachshund, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723968.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24029, Q8IP21

Related

FBpp0080434

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family
NM_165160.3 → NP_723969.1 dachshund, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723969.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24031, Q9VJK6

Related

FBpp0080432

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family
NM_001014487.3 → NP_001014487.1 dachshund, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014487.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24027, Q59DY9

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family
NM_165161.3 → NP_723970.1 dachshund, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723970.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24028, Q8IP20

Related

FBpp0080435

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family
NM_165162.3 → NP_723971.1 dachshund, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723971.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24030, Q8IP19

Related

FBpp0080433

Conserved Domains (1) summary

pfam02437
Location:209 → 310

Ski_Sno; SKI/SNO/DAC family

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q24027		Q24027
Q24028		Q24028
Q24029		Q24029
Q24030		Q24030
Q24031		Q24031
Q59DY9		Q59DY9
Q59DZ0		Q59DZ0
Q6NR49		Q6NR49
Q8IP19		Q8IP19
Q8IP20		Q8IP20
Q8IP21		Q8IP21
Q9VJK6		Q9VJK6