hkb huckebein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hkbprovided by FlyBase
Official Full Name: huckebeinprovided by FlyBase
Primary source: FLYBASE:FBgn0261434
Locus tag: Dmel_CG9768
See related: AllianceGenome:FB:FBgn0261434
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5953; anon-82B3; CG9768; Dmel\CG9768; gurt; Hkb; HKB
Summary: Enables sequence-specific DNA binding activity and transcription corepressor binding activity. Involved in several processes, including germ cell migration; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; embryonic procephalic segment; head epidermis primordium; and neuroblasts. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K and congenital dyserythropoietic anemia type IV. Orthologous to several human genes including KLF1 (KLF transcription factor 1); KLF14 (KLF transcription factor 14); and KLF16 (KLF transcription factor 16). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4345015..4346646, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (170737..172368, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

hkb is required for DIP-alpha expression and target recognition in the Drosophila neuromuscular circuit.
Title: hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit.
Huckebein is part of a combinatorial repression code in the anterior blastoderm.
Title: Huckebein is part of a combinatorial repression code in the anterior blastoderm.
hkb(gurt) mutant embryos reveal that the adjacent endoderm plays a critical role in the later stages of visceral muscle development
Title: Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm.
hkb plays a role in salivary tube development in Drosophila
Title: Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.
Huckebein does not activate transcription; rather, it physically interacts with Glide/Gcm thereby triggering its autoregulation.
Title: Huckebein-mediated autoregulation of Glide/Gcm triggers glia specification.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ectoderm and mesoderm interaction	NAS Non-traceable Author Statement more info	PubMed
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoderm formation	TAS Traceable Author Statement more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior midgut invagination	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain