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    RabGGTb Rab geranylgeranyltransferase subunit beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47757, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RabGGTbprovided by FlyBase
    Official Full Name
    Rab geranylgeranyltransferase subunit betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028970
    Locus tag
    Dmel_CG18627
    See related
    AllianceGenome:FB:FBgn0028970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    betaggt; betaggt II; betaggt-II; CG18627; Dmel\CG18627; GGT-II beta; RabGGTbeta
    Summary
    Contributes to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and head mesoderm. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RabGGTb in Genome Data Viewer
    Location:
    23C1-23C1; 2-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2879112..2880708)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2879112..2880708)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6a Neighboring gene NTPase Neighboring gene Sabbat Neighboring gene lilliputian Neighboring gene RNA-binding protein 9 Neighboring gene Thymidylate synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Wittwer F, et al. Development, 2001 Mar. PMID 11171403
    2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    3. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD. Lopez-Gonzalez R, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31019093, Free PMC Article
    4. Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. Charng WL, et al. PLoS Biol, 2014 Jan. PMID 24492843, Free PMC Article
    5. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Cheng LW, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157870, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to Rab geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein geranylgeranylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab geranylgeranyltransferase subunit beta
    Names
    CG18627-PA
    RabGGTb-PA
    beta subunit of type II geranylgeranyl transferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2879112..2880708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080155.3 → NP_524894.1  Rab geranylgeranyltransferase subunit beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ68
      Related
      FBpp0077316
      Conserved Domains (2) summary
      PLN03201
      Location:33 → 340
      PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional
      cd02894
      Location:29 → 315
      GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ68 Q9XZ68

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