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    Trpc4ap transient receptor potential cation channel, subfamily C, member 4 associated protein [ Mus musculus (house mouse) ]

    Gene ID: 56407, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trpc4approvided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 4 associated proteinprovided by MGI
    Primary source
    MGI:MGI:1930751
    See related
    Ensembl:ENSMUSG00000038324 AllianceGenome:MGI:1930751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    truss; Trrp4ap; mFLJ00177; D2Ertd113e; 4833429F06Rik
    Summary
    Predicted to enable phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within hair follicle maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 93.7), ovary adult (RPKM 61.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpc4ap in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155476197..155534304, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155634277..155692384, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene glutathione synthetase Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene protein C receptor, endothelial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response. Zhu Q, et al. Biochem Biophys Res Commun, 2019 Mar 26. PMID 30765221
    2. TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice. Yu CJ, et al. Hepatology, 2018 Nov. PMID 29704259
    3. TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB. Soond SM, et al. Mol Cell Biol, 2003 Nov. PMID 14585990, Free PMC Article
    4. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRUSS ablation alleviates high fat diet -induced cognitive impairments and metabolic disorder.
      Title: TRUSS inhibition protects against high fat diet (HFD)-stimulated brain injury by alleviation of inflammatory response.
    2. Hepatocyte TRUSS promotes pathological stimuli-induced non alcoholic fatty liver disease and metabolic disorders, through activation of NF-kappaB by promoting ubiquitination and degradation of IkappaBalpha
      Title: TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.
    3. cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)
      Title: TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00177

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hair follicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short transient receptor potential channel 4-associated protein
    Names
    TNF-receptor ubiquitous scaffolding/signaling protein
    Trp4-associated protein TAP1
    rabex-5/Rin2-interacting protein
    transient receptor protein 4, associated protein
    trpc4-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163452.1 → NP_001156924.1  short transient receptor potential channel 4-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001156924.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK171404, AL844852, BC057330
      Consensus CDS
      CCDS50769.1
      UniProtKB/Swiss-Prot
      Q920J6, Q99L03, Q9JLV2
      UniProtKB/TrEMBL
      Q3TDP6, Q571F0
      Related
      ENSMUSP00000037574.6, ENSMUST00000041059.12
      Conserved Domains (1) summary
      pfam12463
      Location:407 → 713
      DUF3689; Protein of unknown function (DUF3689)

    2. NM_019828.2 → NP_062802.2  short transient receptor potential channel 4-associated protein isoform 2

      See identical proteins and their annotated locations for NP_062802.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AK171404, AL844852, BC057330
      Consensus CDS
      CCDS16952.1
      UniProtKB/TrEMBL
      Q571F0
      Related
      ENSMUSP00000099429.5, ENSMUST00000103140.5
      Conserved Domains (1) summary
      pfam12463
      Location:399 → 705
      DUF3689; Protein of unknown function (DUF3689)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155476197..155534304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLV2.2 GenPept UniProtKB/Swiss-Prot:Q9JLV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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