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    Lgi3 leucine-rich repeat LGI family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 213469, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lgi3provided by MGI
    Official Full Name
    leucine-rich repeat LGI family, member 3provided by MGI
    Primary source
    MGI:MGI:2182619
    See related
    Ensembl:ENSMUSG00000033595 AllianceGenome:MGI:2182619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in regulation of exocytosis. Located in juxtaparanode region of axon and synaptic vesicle. Is expressed in several structures, including autopod; gut; nervous system; respiratory system; and retina. Orthologous to human LGI3 (leucine rich repeat LGI family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 127.1), cerebellum adult (RPKM 61.3) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lgi3 in Genome Data Viewer
    Location:
    14 D2; 14 36.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70765982..70775764)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70528547..70538324)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 1 Neighboring gene predicted gene, 52136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70920317-70920426 Neighboring gene surfactant associated protein C Neighboring gene STARR-positive B cell enhancer ABC_E7333 Neighboring gene STARR-positive B cell enhancer ABC_E1901 Neighboring gene receptor accessory protein 4 Neighboring gene lysine demethylase and nuclear receptor corepressor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leucine-rich repeat LGI family member 3
    Names
    leubrin
    leucine-rich glioma-inactivated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425646.1NP_001412575.1  leucine-rich repeat LGI family member 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122268
      UniProtKB/Swiss-Prot
      Q8K406
      UniProtKB/TrEMBL
      Q3V1R3
    2. NM_145219.5NP_660254.1  leucine-rich repeat LGI family member 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660254.1

      Status: VALIDATED

      Source sequence(s)
      AC122268
      Consensus CDS
      CCDS27255.1
      UniProtKB/Swiss-Prot
      Q8K406
      UniProtKB/TrEMBL
      Q3V1R3
      Related
      ENSMUSP00000046705.7, ENSMUST00000047331.8
      Conserved Domains (4) summary
      TIGR00864
      Location:143218
      PCC; polycystin cation channel protein
      sd00031
      Location:6889
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:113172
      LRR_8; Leucine rich repeat
      pfam03736
      Location:270308
      EPTP; EPTP domain

    RNA

    1. NR_189573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122268

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70765982..70775764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)