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    Pou6f2 POU domain, class 6, transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 218030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pou6f2provided by MGI
    Official Full Name
    POU domain, class 6, transcription factor 2provided by MGI
    Primary source
    MGI:MGI:2443631
    See related
    Ensembl:ENSMUSG00000009734 AllianceGenome:MGI:2443631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPF-1; D130006K24Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; eye; and reproductive system. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human POU6F2 (POU class 6 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.0), whole brain E14.5 (RPKM 0.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pou6f2 in Genome Data Viewer
    Location:
    13 A2; 13 6.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (18295683..18797703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (18124960..18382044, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33768 Neighboring gene RIKEN cDNA 4930448F12 gene Neighboring gene ZW10 interactor pseudogene Neighboring gene predicted gene, 31832 Neighboring gene predicted gene, 46402 Neighboring gene STARR-seq mESC enhancer starr_33769 Neighboring gene STARR-seq mESC enhancer starr_33770 Neighboring gene STARR-seq mESC enhancer starr_33771 Neighboring gene STARR-seq mESC enhancer starr_33773 Neighboring gene STARR-seq mESC enhancer starr_33776 Neighboring gene STARR-seq mESC enhancer starr_33777 Neighboring gene VPS41 HOPS complex subunit Neighboring gene STARR-seq mESC enhancer starr_33781 Neighboring gene STARR-seq mESC enhancer starr_33782 Neighboring gene STARR-seq mESC enhancer starr_33784 Neighboring gene predicted gene, 26172

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells. Lin F, et al. Sci Rep, 2024 May 2. PMID 38698014, Free PMC Article
    2. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. Zhou H, et al. J Neurosci, 1996 Apr 1. PMID 8601806, Free PMC Article
    3. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. Perotti D, et al. Genes Chromosomes Cancer, 2001 May. PMID 11284034
    4. The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. Di Renzo F, et al. J Pediatr Hematol Oncol, 2006 Dec. PMID 17164647
    5. Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Xiang M. Dev Biol, 1998 May 15. PMID 9630743

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.
      Title: POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.
    2. Pou6F2 null mice have a corneal thinner than those of wild type littermates. Pou6F2 null retinal ganglion cells die early in the glaucoma model than most retinal ganglion cells.
      Title: Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 6, transcription factor 2
    Names
    retina-derived POU-domain factor-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175006.3 → NP_778171.2  POU domain, class 6, transcription factor 2

      Status: VALIDATED

      Source sequence(s)
      AC154207, AC154356, AC154628, LXEJ02011613
      UniProtKB/TrEMBL
      B2RQZ8
      Related
      ENSMUSP00000139282.3, ENSMUST00000175703.10
      Conserved Domains (2) summary
      pfam00046
      Location:610 → 664
      Homeobox; Homeobox domain
      cl22952
      Location:477 → 586
      Pou; Pou domain - N-terminal to homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      18295683..18797703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157977.1 → XP_036013870.1  POU domain, class 6, transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      B2RQZ8, F6ZW42
      Related
      ENSMUSP00000114173.4, ENSMUST00000139064.11
      Conserved Domains (2) summary
      pfam00046
      Location:647 → 701
      Homeobox; Homeobox domain
      cl22952
      Location:514 → 623
      Pou; Pou domain - N-terminal to homeobox domain

    2. XM_036157978.1 → XP_036013871.1  POU domain, class 6, transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      B2RQZ8
      Conserved Domains (2) summary
      pfam00046
      Location:611 → 665
      Homeobox; Homeobox domain
      cl22952
      Location:514 → 587
      Pou; Pou domain - N-terminal to homeobox domain

    3. XM_036157981.1 → XP_036013874.1  POU domain, class 6, transcription factor 2 isoform X4

      UniProtKB/TrEMBL
      B2RQZ8
      Conserved Domains (2) summary
      pfam00046
      Location:600 → 654
      Homeobox; Homeobox domain
      cl22952
      Location:467 → 576
      Pou; Pou domain - N-terminal to homeobox domain

    4. XM_036157982.1 → XP_036013875.1  POU domain, class 6, transcription factor 2 isoform X5

    5. XM_036157980.1 → XP_036013873.1  POU domain, class 6, transcription factor 2 isoform X3

      UniProtKB/TrEMBL
      B2RQZ8
      Conserved Domains (2) summary
      pfam00046
      Location:610 → 664
      Homeobox; Homeobox domain
      cl22952
      Location:477 → 586
      Pou; Pou domain - N-terminal to homeobox domain

    6. XM_036157979.1 → XP_036013872.1  POU domain, class 6, transcription factor 2 isoform X3

      UniProtKB/TrEMBL
      B2RQZ8
      Conserved Domains (2) summary
      pfam00046
      Location:610 → 664
      Homeobox; Homeobox domain
      cl22952
      Location:477 → 586
      Pou; Pou domain - N-terminal to homeobox domain

    7. XM_036157983.1 → XP_036013876.1  POU domain, class 6, transcription factor 2 isoform X6

    RNA

    1. XR_004938015.1 RNA Sequence

    2. XR_004938014.1 RNA Sequence

    3. XR_004938016.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJI4.1 GenPept UniProtKB/Swiss-Prot:Q8BJI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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