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    Zer1 zyg-11 related, cell cycle regulator [ Mus musculus (house mouse) ]

    Gene ID: 227693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zer1provided by MGI
    Official Full Name
    zyg-11 related, cell cycle regulatorprovided by MGI
    Primary source
    MGI:MGI:2442511
    See related
    Ensembl:ENSMUSG00000039686 AllianceGenome:MGI:2442511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zyg11bl; C230075L19Rik
    Summary
    Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 30.7), thymus adult (RPKM 30.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zer1 in Genome Data Viewer
    Location:
    2 B; 2 21.16 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29987295..30016299, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30097283..30126287, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene protein kinase N3 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein zer-1 homolog
    Names
    zer-1 homolog
    zyg-11 homolog B-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290503.1 → NP_001277432.1  protein zer-1 homolog isoform b

      See identical proteins and their annotated locations for NP_001277432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      BC048924, BC057021, BY749660
      Consensus CDS
      CCDS71017.1
      UniProtKB/TrEMBL
      Q3U297
      Related
      ENSMUSP00000109307.2, ENSMUST00000113677.3
      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 600
      ARM; armadillo repeat [structural motif]

    2. NM_178694.4 → NP_848809.2  protein zer-1 homolog isoform a

      See identical proteins and their annotated locations for NP_848809.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC048924, BY749660
      Consensus CDS
      CCDS15870.1
      UniProtKB/Swiss-Prot
      A2BEA2, Q6PGH5, Q80ZJ6, Q8BG38
      Related
      ENSMUSP00000046441.9, ENSMUST00000044751.14
      Conserved Domains (3) summary
      cd00020
      Location:529 → 655
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:575 → 613
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29987295..30016299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317305.3 → XP_017172794.1  protein zer-1 homolog isoform X1

      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 600
      ARM; armadillo repeat [structural motif]

    2. XM_036160810.1 → XP_036016703.1  protein zer-1 homolog isoform X3

      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:560 → 598
      ARM; armadillo repeat [structural motif]

    3. XM_006497928.5 → XP_006497991.1  protein zer-1 homolog isoform X1

      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 600
      ARM; armadillo repeat [structural motif]

    4. XM_036160808.1 → XP_036016701.1  protein zer-1 homolog isoform X2

      UniProtKB/TrEMBL
      Q3U297
      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 600
      ARM; armadillo repeat [structural motif]

    5. XM_017317313.3 → XP_017172802.1  protein zer-1 homolog isoform X1

      Conserved Domains (2) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00043
      Location:562 → 600
      ARM; armadillo repeat [structural motif]

    6. XM_017317318.2 → XP_017172807.1  protein zer-1 homolog isoform X4

      Conserved Domains (1) summary
      sd00034
      Location:82 → 104
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZJ6.1 GenPept UniProtKB/Swiss-Prot:Q80ZJ6

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