Skic8 SKI8 subunit of superkiller complex [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Skic8provided by MGI
Official Full Name: SKI8 subunit of superkiller complexprovided by MGI
Primary source: MGI:MGI:1917493
See related: Ensembl:ENSMUSG00000061559 AllianceGenome:MGI:1917493
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ski8; REC14; Wdr61; 2700038L12Rik; 2810418I05Rik
Summary: Predicted to be involved in RNA metabolic process; negative regulation of myeloid cell differentiation; and rescue of stalled ribosome. Part of Cdc73/Paf1 complex. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SKIC8 (SKI8 subunit of superkiller complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 61.0), bladder adult (RPKM 36.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.73 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54624437..54641833, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54717153..54734549, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236137 (e-PCR)
- UniSTS:236137

AV358213 (e-PCR)
- UniSTS:179903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cdc73/Paf1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Cdc73/Paf1 complex	ISO Inferred from Sequence Orthology more info
part_of Cdc73/Paf1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Ski complex	ISO Inferred from Sequence Orthology more info
part_of Ski complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: superkiller complex protein 8

Names: SKI8 subunit of superkiller complex protein; WD repeat domain 61; WD repeat-containing protein 61; meiotic recombination protein REC14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025375.2 → NP_001020546.1 superkiller complex protein 8 isoform a

See identical proteins and their annotated locations for NP_001020546.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.

Source sequence(s)

AC159892, AK012342, AK167706

Consensus CDS

CCDS23194.1

UniProtKB/Swiss-Prot

Q3U562, Q9CZP1, Q9ERF3

UniProtKB/TrEMBL

A0MNP4

Related

ENSMUSP00000113560.2, ENSMUST00000121204.8

Conserved Domains (2) summary

cd00200
Location:13 → 302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:110 → 146

7WD40; WD40 repeat [structural motif]
NM_001025376.2 → NP_001020547.1 superkiller complex protein 8 isoform b

See identical proteins and their annotated locations for NP_001020547.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site at an internal exon compared to variant 1. This difference results in predicted translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded protein (isoform b) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AC159892, AK010283

Consensus CDS

CCDS59747.1

UniProtKB/TrEMBL

D6RDC7, Q9CWZ4

Related

ENSMUSP00000123077.3, ENSMUST00000130368.8

Conserved Domains (2) summary

cd00200
Location:12 → 204

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:12 → 48

7WD40; WD40 repeat [structural motif]
NM_023191.3 → NP_075680.1 superkiller complex protein 8 isoform a

See identical proteins and their annotated locations for NP_075680.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).

Source sequence(s)

AC159892, AK013114

Consensus CDS

CCDS23194.1

UniProtKB/Swiss-Prot

Q3U562, Q9CZP1, Q9ERF3

UniProtKB/TrEMBL

A0MNP4

Related

ENSMUSP00000056359.7, ENSMUST00000051822.13

Conserved Domains (2) summary

cd00200
Location:13 → 302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:110 → 146

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

54624437..54641833 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242785.2 → XP_011241087.1 superkiller complex protein 8 isoform X2

See identical proteins and their annotated locations for XP_011241087.1

UniProtKB/TrEMBL

D6RDC7, Q9CWZ4

Conserved Domains (2) summary

cd00200
Location:12 → 204

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:12 → 48

7WD40; WD40 repeat [structural motif]
XM_036155174.1 → XP_036011067.1 superkiller complex protein 8 isoform X1

UniProtKB/Swiss-Prot

Q3U562, Q9CZP1, Q9ERF3

UniProtKB/TrEMBL

A0MNP4

Conserved Domains (2) summary

cd00200
Location:13 → 302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:110 → 146

7WD40; WD40 repeat [structural motif]