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    Fitm2 fat storage-inducing transmembrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 228859, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fitm2provided by MGI
    Official Full Name
    fat storage-inducing transmembrane protein 2provided by MGI
    Primary source
    MGI:MGI:2444508
    See related
    Ensembl:ENSMUSG00000048486 AllianceGenome:MGI:2444508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fit2; D930001I22Rik
    Summary
    Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including intracellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Acts upstream of or within sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 53.0), adrenal adult (RPKM 50.4) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fitm2 in Genome Data Viewer
    Location:
    2 H3; 2 84.29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163310623..163314549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163468703..163472629, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900093K20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1608 Neighboring gene oxidative stress responsive serine rich 1 Neighboring gene ganglioside-induced differentiation-associated protein 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_06310 Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4516 Neighboring gene R3H domain containing-like Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coenzyme A diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables coenzyme A diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables diacylglycerol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triglyceride binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty-acyl-CoA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid droplet formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid droplet organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sequestering of triglyceride IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    acyl-coenzyme A diphosphatase FITM2
    Names
    fat-inducing protein 2
    fat-inducing transcript 2
    NP_775573.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173397.4NP_775573.1  acyl-coenzyme A diphosphatase FITM2

      See identical proteins and their annotated locations for NP_775573.1

      Status: PROVISIONAL

      Source sequence(s)
      AK043244
      Consensus CDS
      CCDS38315.1
      UniProtKB/Swiss-Prot
      B9EHX3, P59266, Q5BKP7
      Related
      ENSMUSP00000105045.2, ENSMUST00000109418.2
      Conserved Domains (1) summary
      pfam10261
      Location:51234
      Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163310623..163314549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)