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    Cdc20b cell division cycle 20B [ Mus musculus (house mouse) ]

    Gene ID: 238896, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc20bprovided by MGI
    Official Full Name
    cell division cycle 20Bprovided by MGI
    Primary source
    MGI:MGI:3644472
    See related
    Ensembl:ENSMUSG00000078926 AllianceGenome:MGI:3644472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG238896; EG622422
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in de novo centriole assembly. Located in deuterosome. Orthologous to human CDC20B (cell division cycle 20B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.0), CNS E14 (RPKM 0.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc20b in Genome Data Viewer
    Location:
    13 D2.2; 13 63.93 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113171514..113257553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113034975..113121019)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cyclin O Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene STARR-positive B cell enhancer ABC_E5420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:113814136-113814301 Neighboring gene microRNA 449c Neighboring gene microRNA 449b Neighboring gene microRNA 449a Neighboring gene glutathione peroxidase 8 (putative) Neighboring gene granzyme A Neighboring gene RIKEN cDNA 1700084D21 gene Neighboring gene granzyme K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Revinski DR, et al. Nat Commun, 2018 Nov 7. PMID 30405130, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC20B protein associates to deuterosomes and is required for centriole release and subsequent cilia production.
      Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in de novo centriole assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in de novo centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in deuterosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in deuterosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 20 homolog B
    Names
    cell division cycle 20 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281487.1 → NP_001268416.1  cell division cycle protein 20 homolog B

      Status: VALIDATED

      Source sequence(s)
      AC159207, AC165265
      Consensus CDS
      CCDS59591.1
      UniProtKB/Swiss-Prot
      D3Z3I0
      UniProtKB/TrEMBL
      M0QWN1
      Related
      ENSMUSP00000104867.2, ENSMUST00000109244.9
      Conserved Domains (3) summary
      COG2319
      Location:230 → 518
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:237 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      113171514..113257553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247263.2 → XP_030103123.1  cell division cycle protein 20 homolog B isoform X8

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:184 → 510
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:208 → 245
      7WD40; WD40 repeat [structural motif]

    2. XM_011244659.3 → XP_011242961.1  cell division cycle protein 20 homolog B isoform X1

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 538
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    3. XM_011244662.3 → XP_011242964.1  cell division cycle protein 20 homolog B isoform X5

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 478
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    4. XM_011244660.3 → XP_011242962.1  cell division cycle protein 20 homolog B isoform X2

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    5. XM_011244661.3 → XP_011242963.1  cell division cycle protein 20 homolog B isoform X4

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    6. XM_036158047.1 → XP_036013940.1  cell division cycle protein 20 homolog B isoform X6

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    7. XM_006517655.4 → XP_006517718.1  cell division cycle protein 20 homolog B isoform X7

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:212 → 495
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    8. XM_006517653.4 → XP_006517716.1  cell division cycle protein 20 homolog B isoform X3

      UniProtKB/TrEMBL
      M0QWN1
      Conserved Domains (2) summary
      COG2319
      Location:230 → 535
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:236 → 273
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_873755.3 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z3I0.1 GenPept UniProtKB/Swiss-Prot:D3Z3I0

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