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    Lmo2 LIM domain only 2 [ Mus musculus (house mouse) ]

    Gene ID: 16909, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Lmo2provided by MGI
    Official Full Name
    LIM domain only 2provided by MGI
    Primary source
    MGI:MGI:102811
    See related
    Ensembl:ENSMUSG00000032698 AllianceGenome:MGI:102811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttg2; Rbtn2; Rbtn-2; Rhom-2
    Summary
    Enables chromatin binding activity. Contributes to DNA binding activity. Involved in negative regulation of erythrocyte differentiation. Acts upstream of or within embryonic hemopoiesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study acute lymphoblastic leukemia. Orthologous to human LMO2 (LIM domain only 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 70.3), liver E14.5 (RPKM 65.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmo2 in Genome Data Viewer
    Location:
    2 E2; 2 54.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103788309..103812223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103957903..103981878)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA of erythroid differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E9523 Neighboring gene STARR-positive B cell enhancer ABC_E638 Neighboring gene predicted gene, 39896 Neighboring gene predicted gene, 38515 Neighboring gene RIKEN cDNA 4931422A03 gene Neighboring gene STARR-seq mESC enhancer starr_05277 Neighboring gene STARR-positive B cell enhancer ABC_E5954 Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene F-box protein 3 Neighboring gene predicted gene, 24644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice. Neale GA, et al. Blood, 1995 Oct 15. PMID 7579400
    2. The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia. Curtis DJ, et al. Clin Cancer Res, 2010 Dec 1. PMID 20861166
    3. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. Davé UP, et al. PLoS Genet, 2009 May. PMID 19461887, Free PMC Article
    4. Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Landry JR, et al. Blood, 2009 Jun 4. PMID 19171877
    5. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Cleveland SM, et al. Exp Hematol, 2014 Jul. PMID 24792354, Free PMC Article

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
      Title: Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
    2. The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
      Title: The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
    3. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
      Title: LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
    4. NHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML, associated with a loss of multipotent progenitors in the bone marrow. Thus multiple T cell oncogenes induce thymocyte self-renewal via Lmo2/Lyl1.
      Title: The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.
    5. Transient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression, and histologically, transcriptionally, and genetically similar to human LMO2-driven T-ALL.
      Title: Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.
    6. Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors.
      Title: Epigenetic dysregulation of ZEB1 is involved in LMO2-promoted T-cell acute lymphoblastic leukaemia leukaemogenesis.
    7. Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
      Title: LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
    8. DNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling.
      Title: Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
    9. Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
      Title: Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
    10. HHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
      Title: LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rhombotin-2
    Names
    LIM domain only protein 2
    LIM only 2
    LMO-2
    T-cell translocation protein 2
    cysteine-rich protein TTG-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142335.2 → NP_001135807.1  rhombotin-2 isoform 2

      See identical proteins and their annotated locations for NP_001135807.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences allow translation initiation from an alternate start codon and an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BX640578
      Consensus CDS
      CCDS50651.1
      UniProtKB/TrEMBL
      A2BHP5
      Related
      ENSMUSP00000106773.2, ENSMUST00000111143.8
      Conserved Domains (2) summary
      cd09384
      Location:92 → 147
      LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
      cd09385
      Location:156 → 211
      LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

    2. NM_001142336.1 → NP_001135808.1  rhombotin-2 isoform 3

      See identical proteins and their annotated locations for NP_001135808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AK013416, AV361906, BX523983, CX226855, CX234489
      Consensus CDS
      CCDS50652.1
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2
      Related
      ENSMUSP00000117703.2, ENSMUST00000123437.8
      Conserved Domains (2) summary
      cd09384
      Location:30 → 85
      LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
      cd09385
      Location:94 → 149
      LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

    3. NM_001142337.2 → NP_001135809.1  rhombotin-2 isoform 3

      See identical proteins and their annotated locations for NP_001135809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      BX640578
      Consensus CDS
      CCDS50652.1
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2
      Related
      ENSMUSP00000128317.2, ENSMUST00000170926.8
      Conserved Domains (2) summary
      cd09384
      Location:30 → 85
      LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
      cd09385
      Location:94 → 149
      LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

    4. NM_001420375.1 → NP_001407304.1  rhombotin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX640578

    5. NM_001420376.1 → NP_001407305.1  rhombotin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX640578
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2

    6. NM_001420377.1 → NP_001407306.1  rhombotin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX640578
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2

    7. NM_001420378.1 → NP_001407307.1  rhombotin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX640578
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2

    8. NM_001420379.1 → NP_001407308.1  rhombotin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX640578
      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2

    9. NM_001420380.1 → NP_001407309.1  rhombotin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX640578

    10. NM_001420381.1 → NP_001407310.1  rhombotin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX640578

    11. NM_001420382.1 → NP_001407311.1  rhombotin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX640578

    12. NM_008505.5 → NP_032531.2  rhombotin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BX640578
      Consensus CDS
      CCDS16482.2
      UniProtKB/TrEMBL
      A2BHP3
      Related
      ENSMUSP00000106770.3, ENSMUST00000111140.3
      Conserved Domains (2) summary
      cd09384
      Location:100 → 155
      LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
      cd09385
      Location:164 → 219
      LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103788309..103812223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498820.4 → XP_006498883.1  rhombotin-2 isoform X1

      See identical proteins and their annotated locations for XP_006498883.1

      UniProtKB/Swiss-Prot
      P25801
      UniProtKB/TrEMBL
      A2BHP2, Q544Z2
      Conserved Domains (2) summary
      cd09384
      Location:30 → 85
      LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
      cd09385
      Location:94 → 149
      LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25801.1 GenPept UniProtKB/Swiss-Prot:P25801

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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