Zfp451 zinc finger protein 451 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp451provided by MGI
Official Full Name: zinc finger protein 451provided by MGI
Primary source: MGI:MGI:2137896
See related: Ensembl:ENSMUSG00000042197 AllianceGenome:MGI:2137896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf451; COASTER; mKIAA1702; Kiaa0576-hp; 4930515K21Rik; 4933435G09Rik
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SUMO ligase activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; and metanephros. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 5.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 12.81 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (33800622..33854683, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (33761541..33815602, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
Title: Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
a regulatory role of ZNF451-1 in fine-tuning physiological PML levels
Title: The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234098

NoName (e-PCR)
- UniSTS:234100

D1Mit318 (e-PCR), detects polymorphism
- UniSTS:128676

AI596398 (e-PCR)
- UniSTS:178371

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO ligase activity	ISO Inferred from Sequence Orthology more info
enables SUMO ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription initiation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 SUMO-protein ligase ZNF451

Names: E3 SUMO-protein transferase ZNF451

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290699.1 → NP_001277628.1 E3 SUMO-protein ligase ZNF451 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC163668, AI596398, AK015797, AK030088

UniProtKB/TrEMBL

Q6P6L8

Conserved Domains (1) summary

cd18721
Location:722 → 838

PIN_ZNF451-like; LabA-like PIN domain of human zinc finger protein 451 and related proteins
NM_001290700.1 → NP_001277629.1 E3 SUMO-protein ligase ZNF451 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a distinct 3' structure and 3' terminus, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC163668, AK015797

Consensus CDS

CCDS69873.1

UniProtKB/TrEMBL

Q80TA4, Q8VCL4

Related

ENSMUSP00000044372.6, ENSMUST00000044455.8

Conserved Domains (1) summary

pfam11560
Location:357 → 492

LAP2alpha; Lamina-associated polypeptide 2 alpha
NM_001359274.1 → NP_001346203.1 E3 SUMO-protein ligase ZNF451 isoform 4

Status: VALIDATED

Source sequence(s)

AC163668

UniProtKB/TrEMBL

Q6P6L8
NM_001359275.1 → NP_001346204.1 E3 SUMO-protein ligase ZNF451 isoform 5

Status: VALIDATED

Source sequence(s)

AC163668

UniProtKB/TrEMBL

Q6P6L8
NM_133817.3 → NP_598578.1 E3 SUMO-protein ligase ZNF451 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC163668, AI596398, AK015797, AK030088

Consensus CDS

CCDS14865.1

UniProtKB/Swiss-Prot

Q8C0P7

UniProtKB/TrEMBL

Q6P6L8

Related

ENSMUSP00000019861.7, ENSMUST00000019861.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

33800622..33854683 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154651.1 → XP_036010544.1 E3 SUMO-protein ligase ZNF451 isoform X1

UniProtKB/TrEMBL

Q6P6L8

Conserved Domains (1) summary

pfam18479
Location:741 → 858

PIN_11; PIN like domain
XM_036154666.1 → XP_036010559.1 E3 SUMO-protein ligase ZNF451 isoform X2

UniProtKB/TrEMBL

Q6P6L8

Conserved Domains (1) summary

pfam18479
Location:553 → 670

PIN_11; PIN like domain
XM_030243891.2 → XP_030099751.1 E3 SUMO-protein ligase ZNF451 isoform X1

UniProtKB/TrEMBL

Q6P6L8

Conserved Domains (1) summary

pfam18479
Location:741 → 858

PIN_11; PIN like domain