Klhl24 kelch-like 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl24provided by MGI
Official Full Name: kelch-like 24provided by MGI
Primary source: MGI:MGI:1923035
See related: Ensembl:ENSMUSG00000062901 AllianceGenome:MGI:1923035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110046J11Rik; 4930429H24Rik; 6530402O20Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intermediate filament organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in adherens junction and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; ganglia; and olfactory epithelium. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and familial hypertrophic cardiomyopathy. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 15.9), bladder adult (RPKM 11.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 12.36 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (19916286..19947976)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (20097553..20129226)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin.
Title: Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin.
KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia.
Title: KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127123 (e-PCR)
- UniSTS:209182

AA516607 (e-PCR)
- UniSTS:209183

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in desmosome	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch-like protein 24

Names: KRIP6; kainate receptor-interacting protein for GluR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029436.3 → NP_083712.4 kelch-like protein 24

Status: VALIDATED

Source sequence(s)

AC165282

Consensus CDS

CCDS28042.1

UniProtKB/Swiss-Prot

Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3

Related

ENSMUSP00000023509.4, ENSMUST00000023509.5

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

19916286..19947976

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522687.5 → XP_006522750.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)
XM_036160174.1 → XP_036016067.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)