Cacng4 calcium channel, voltage-dependent, gamma subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacng4provided by MGI
Official Full Name: calcium channel, voltage-dependent, gamma subunit 4provided by MGI
Primary source: MGI:MGI:1859167
See related: Ensembl:ENSMUSG00000020723 AllianceGenome:MGI:1859167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium channel regulator activity; ionotropic glutamate receptor binding activity; and voltage-gated calcium channel activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within transmission of nerve impulse. Located in somatodendritic compartment. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 47.6), CNS E18 (RPKM 44.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 70.29 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (107623183..107685532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (107732357..107794706, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cacng4 (e-PCR), detects polymorphism
- UniSTS:499001

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmission of nerve impulse	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-4 subunit

Names: TARP gamma-4; neuronal voltage-gated calcium channel gamma-4 subunit; transmembrane AMPAR regulatory protein gamma-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.