Slc39a12 solute carrier family 39 (zinc transporter), member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a12provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 12provided by MGI
Primary source: MGI:MGI:2139274
See related: Ensembl:ENSMUSG00000036949 AllianceGenome:MGI:2139274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm731
Summary: Enables zinc ion transmembrane transporter activity. Acts upstream of or within several processes, including regulation of microtubule polymerization; regulation of neuron projection development; and zinc ion import across plasma membrane. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in embryo mesenchyme; forelimb; and nervous system. Orthologous to human SLC39A12 (solute carrier family 39 member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 13.0), cortex adult (RPKM 12.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A2; 2 10.56 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (14345476..14499787)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (14388316..14494977)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis.
Title: Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis.
Data indicate that ZIP12 (slc39a12) is a Zn(2+) uptake transporter with a conserved pattern of high expression in the mouse and Xenopus nervous system.
Title: Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

D2Ucl2 (e-PCR), detects polymorphism
- UniSTS:142348

AW046938 (e-PCR)
- UniSTS:165146

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to decreased oxygen levels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc transporter ZIP12

Names: ZIP-12; solute carrier family 39 member 12; zrt- and Irt-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012305.3 → NP_001012305.1 zinc transporter ZIP12 isoform 1 precursor

See identical proteins and their annotated locations for NP_001012305.1

Status: VALIDATED

Source sequence(s)

AL844558

Consensus CDS

CCDS15701.1

UniProtKB/Swiss-Prot

A2AQ76, Q5FWH7

Related

ENSMUSP00000080911.7, ENSMUST00000082290.8

Conserved Domains (1) summary

pfam02535
Location:369 → 681

Zip; ZIP Zinc transporter
NM_001409652.1 → NP_001396581.1 zinc transporter ZIP12 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL844558, AL845290
NM_001409653.1 → NP_001396582.1 zinc transporter ZIP12 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL844558, AL845290

UniProtKB/Swiss-Prot

A2AQ76, Q5FWH7
NM_001409654.1 → NP_001396583.1 zinc transporter ZIP12 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL844558, AL845290

UniProtKB/Swiss-Prot

A2AQ76, Q5FWH7
NM_001409655.1 → NP_001396584.1 zinc transporter ZIP12 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL844558
NM_001409657.1 → NP_001396586.1 zinc transporter ZIP12 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL844558, AL845290
NM_001409658.1 → NP_001396587.1 zinc transporter ZIP12 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AL844558
NM_001409659.1 → NP_001396588.1 zinc transporter ZIP12 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AL844558
NM_001409660.1 → NP_001396589.1 zinc transporter ZIP12 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AL844558, AL845290
NM_001409661.1 → NP_001396590.1 zinc transporter ZIP12 isoform 7

Status: VALIDATED

Source sequence(s)

AL844558
NM_001409662.1 → NP_001396591.1 zinc transporter ZIP12 isoform 7

Status: VALIDATED

Source sequence(s)

AL844558, AL845290
NM_001409663.1 → NP_001396592.1 zinc transporter ZIP12 isoform 8 precursor

Status: VALIDATED

Source sequence(s)

AL844558