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    Prrc2b proline-rich coiled-coil 2B [ Mus musculus (house mouse) ]

    Gene ID: 227723, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrc2bprovided by MGI
    Official Full Name
    proline-rich coiled-coil 2Bprovided by MGI
    Primary source
    MGI:MGI:1923304
    See related
    Ensembl:ENSMUSG00000039262 AllianceGenome:MGI:1923304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bat2l; Bat2l1; mKIAA0515; D430039P21; 5830434P21Rik
    Summary
    Acts upstream of or within in utero embryonic development. Is expressed in nervous system and sensory organ. Orthologous to human PRRC2B (proline rich coiled-coil 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 35.1), ovary adult (RPKM 32.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrc2b in Genome Data Viewer
    Location:
    2 B; 2 22.05 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32041002..32124549)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32151031..32234537)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 78, member A Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene STARR-seq mESC enhancer starr_04169 Neighboring gene VISTA enhancer mm194 Neighboring gene STARR-seq mESC enhancer starr_04172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32011222-32011331 Neighboring gene STARR-seq mESC enhancer starr_04177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32023467-32023668 Neighboring gene STARR-seq mESC enhancer starr_04183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32036927-32037171 Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10094 Neighboring gene uridine-cytidine kinase 1 Neighboring gene 60S ribosomal protein L36 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice. Li S, et al. Adv Sci (Weinh), 2023 Sep. PMID 37395402, Free PMC Article
    2. PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Zhang Y, et al. Cell Rep, 2024 Mar 26. PMID 38507412
    3. Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Martinez-Mayer J, et al. Genome Med, 2024 May 31. PMID 38822427, Free PMC Article
    4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    5. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.
      Title: The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2B
    Names
    HLA-B-associated transcript 2-like 1
    proline-rich coiled-coil protein 2B
    protein BAT2-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159634.1 → NP_001153106.1  protein PRRC2B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147677, BC055116, BP753788
      Consensus CDS
      CCDS50565.1
      UniProtKB/TrEMBL
      F8WHT3
      Related
      ENSMUSP00000064892.9, ENSMUST00000069817.15
      Conserved Domains (2) summary
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus
      pfam07223
      Location:1932 → 2189
      DUF1421; Protein of unknown function (DUF1421)

    2. NM_172661.3 → NP_766249.2  protein PRRC2B isoform 2

      See identical proteins and their annotated locations for NP_766249.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, lacks an alternate exon in the 3' coding region that results in a frameshift of the C-terminus, and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, includes an extra amino acid, and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK147677, BC055116, BP753788
      Consensus CDS
      CCDS15907.1
      UniProtKB/Swiss-Prot
      A2AN31, Q7TPM1, Q8C755
      UniProtKB/TrEMBL
      F7AYW2
      Related
      ENSMUSP00000035734.8, ENSMUST00000036691.14
      Conserved Domains (2) summary
      pfam03153
      Location:1261 → 1441
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32041002..32124549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497948.5 → XP_006498011.1  protein PRRC2B isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:1741 → 2176
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    2. XM_006497951.5 → XP_006498014.1  protein PRRC2B isoform X4

      Conserved Domains (2) summary
      pfam09606
      Location:1802 → 2123
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    3. XM_030249906.2 → XP_030105766.1  protein PRRC2B isoform X5

      Conserved Domains (2) summary
      pfam09606
      Location:1801 → 2122
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    4. XM_006497949.5 → XP_006498012.1  protein PRRC2B isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:1711 → 2146
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    5. XM_006497950.5 → XP_006498013.1  protein PRRC2B isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:1710 → 2145
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    6. XM_006497952.5 → XP_006498015.1  protein PRRC2B isoform X6

      UniProtKB/TrEMBL
      F7AYW2
      Related
      ENSMUSP00000116429.2, ENSMUST00000132459.8
      Conserved Domains (2) summary
      PHA03247
      Location:1054 → 1489
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    7. XM_006497953.5 → XP_006498016.1  protein PRRC2B isoform X7

      See identical proteins and their annotated locations for XP_006498016.1

      UniProtKB/TrEMBL
      F7AYW2
      Conserved Domains (2) summary
      PHA03247
      Location:1053 → 1488
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    8. XM_030249910.2 → XP_030105770.1  protein PRRC2B isoform X8

      UniProtKB/TrEMBL
      F7AYW2
      Conserved Domains (2) summary
      PHA03247
      Location:1024 → 1459
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    9. XM_030249911.2 → XP_030105771.1  protein PRRC2B isoform X9

      UniProtKB/TrEMBL
      F7AYW2
      Conserved Domains (2) summary
      PHA03247
      Location:1023 → 1458
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    10. XM_030249897.2 → XP_030105757.1  protein PRRC2B isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:1741 → 2176
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPM1.1 GenPept UniProtKB/Swiss-Prot:Q7TPM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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