Slbp stem-loop binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slbpprovided by MGI
Official Full Name: stem-loop binding proteinprovided by MGI
Primary source: MGI:MGI:108402
See related: Ensembl:ENSMUSG00000004642 AllianceGenome:MGI:108402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables histone pre-mRNA stem-loop binding activity and mRNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in cytoplasm and nucleus. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system gland; and pancreas. Orthologous to human SLBP (stem-loop histone mRNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 77.2), liver E14.5 (RPKM 59.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33797399..33809918, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33640055..33652574, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLBP overexpression caused by Fbxo30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation. The finding uncovers an unidentified pathway-controlling chromosome segregation and cell progress.
Title: Fbxo30 regulates chromosome segregation of oocyte meiosis.
During maturation, Slbp mRNA becomes polyadenylated and translationally activated. Proteasomal activity is required both to initiate and to sustain translational activation.
Title: Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.
Maternally encoded Slbp is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways.
Title: Maternally encoded stem-loop-binding protein is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways.
SLBP is an essential component of the mechanism by which growing oocytes of the mouse accumulate the histones that support early embryonic development.
Title: Stem-loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouse.
histone synthesis in immature and maturing oocytes is governed by a translational control mechanism that is directly regulated by changes in the amount of SLBP
Title: The stem-loop binding protein regulates translation of histone mRNA during mammalian oogenesis.
Inhibition of NF kappa B in TNF alpha-treated primary mouse hepatocytes is associated with increased S-phase cell cycle retention and decreased stem loop binding protein.
Title: TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein.
SLBP expression and activity differ in mouse oocytes and early embryos compared with somatic cells.
Title: Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

RH125856 (e-PCR)
- UniSTS:162594

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:235162

RH124873 (e-PCR)
- UniSTS:161695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone pre-mRNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone pre-mRNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cap-dependent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone mRNA stem-loop binding complex	ISO Inferred from Sequence Orthology more info
part_of histone pre-mRNA 3'end processing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone pre-mRNA 3'end processing complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone RNA hairpin-binding protein

Names: histone stem-loop-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289724.1 → NP_001276653.1 histone RNA hairpin-binding protein isoform 2

See identical proteins and their annotated locations for NP_001276653.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC132233, AC162898, AK162121, BE979466

Consensus CDS

CCDS80257.1

UniProtKB/TrEMBL

Q3TSD8, Q8K2W7

Related

ENSMUSP00000098906.4, ENSMUST00000101354.10

Conserved Domains (1) summary

pfam15247
Location:110 → 177

SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain
NM_001289725.1 → NP_001276654.1 histone RNA hairpin-binding protein isoform 3

See identical proteins and their annotated locations for NP_001276654.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC132233, AC162898, AK162121, BE979466

UniProtKB/TrEMBL

Q3TSD8

Conserved Domains (1) summary

pfam15247
Location:95 → 162

SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain
NM_009193.2 → NP_033219.1 histone RNA hairpin-binding protein isoform 1

See identical proteins and their annotated locations for NP_033219.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC132233, AC162898, AK162121, BE979466

Consensus CDS

CCDS19205.1

UniProtKB/Swiss-Prot

P97440

UniProtKB/TrEMBL

Q3TSD8, Q3U4T7

Related

ENSMUSP00000062930.8, ENSMUST00000057551.14

Conserved Domains (1) summary

pfam15247
Location:130 → 197

SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain