Rbpms RNA binding protein gene with multiple splicing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbpmsprovided by MGI
Official Full Name: RNA binding protein gene with multiple splicingprovided by MGI
Primary source: MGI:MGI:1334446
See related: Ensembl:ENSMUSG00000031586 AllianceGenome:MGI:1334446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RBP-MS; hermes; 2010300K22Rik; 2700019M19Rik
Summary: Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in several processes, including SMAD protein signal transduction; regulation of alternative mRNA splicing, via spliceosome; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; gut; heart; retina; and urinary system. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 24.2), bladder adult (RPKM 22.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.85 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34272671..34419925, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (33782643..33929922, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
Title: Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
Title: RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
Title: RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Title: Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU017537 (e-PCR)
- UniSTS:159751

Rbpms (e-PCR), detects polymorphism
- UniSTS:479243

Rbpms (e-PCR), detects polymorphism
- UniSTS:465492

D8Mit258 (e-PCR), detects polymorphism
- UniSTS:131467

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA CDS binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA intronic binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA intronic binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RNA-binding protein with multiple splicing

Names: HEart, RRM Expressed Sequence; RNA-binding protein with multiple splicing (RBP-MS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042674.2 → NP_001036139.1 RNA-binding protein with multiple splicing isoform 1

See identical proteins and their annotated locations for NP_001036139.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).

Source sequence(s)

AC162523, AK003434, AK041118

Consensus CDS

CCDS40317.1

UniProtKB/Swiss-Prot

Q78HG1, Q9CPU5, Q9WVB0

Related

ENSMUSP00000055813.5, ENSMUST00000053251.12

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
NM_001042675.2 → NP_001036140.1 RNA-binding protein with multiple splicing isoform 3

See identical proteins and their annotated locations for NP_001036140.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC162523, AK012265

Consensus CDS

CCDS40318.1

UniProtKB/Swiss-Prot

Q9WVB0

Related

ENSMUSP00000033995.7, ENSMUST00000033995.14

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
NM_001286168.1 → NP_001273097.1 RNA-binding protein with multiple splicing isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 4) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC162523, AK003434, AK079238

Consensus CDS

CCDS72112.1

UniProtKB/TrEMBL

Q8C586, T1ECW4

Related

ENSMUSP00000033994.9, ENSMUST00000033994.15

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
NM_019733.3 → NP_062707.1 RNA-binding protein with multiple splicing isoform 1

See identical proteins and their annotated locations for NP_062707.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC162523, AK003434, AK041118, AK079238

Consensus CDS

CCDS40317.1

UniProtKB/Swiss-Prot

Q78HG1, Q9CPU5, Q9WVB0

Related

ENSMUSP00000140387.2, ENSMUST00000191473.7

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

34272671..34419925 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509037.4 → XP_006509100.3 RNA-binding protein with multiple splicing isoform X4

Conserved Domains (1) summary

cd12682
Location:40 → 115

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_006509035.5 → XP_006509098.1 RNA-binding protein with multiple splicing isoform X2

Conserved Domains (1) summary

cd12682
Location:23 → 98

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_006509034.5 → XP_006509097.1 RNA-binding protein with multiple splicing isoform X1

Conserved Domains (1) summary

cd12682
Location:40 → 115

RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)
XM_036153838.1 → XP_036009731.1 RNA-binding protein with multiple splicing isoform X3

Conserved Domains (1) summary

cd12682
Location:40 → 115

RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)