Cd209a CD209a antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd209aprovided by MGI
Official Full Name: CD209a antigenprovided by MGI
Primary source: MGI:MGI:2157942
See related: Ensembl:ENSMUSG00000031494 AllianceGenome:MGI:2157942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIRE; CD209; CDSIGN; Dcsign; SIGNR5; DC-SIGN; SIGN-R1; DC-SIGN1
Summary: Enables D-mannose binding activity and carbohydrate derivative binding activity. Predicted to be involved in immune response. Predicted to act upstream of or within regulation of T cell proliferation. Located in cell surface. Human ortholog(s) of this gene implicated in Coronavirus infectious disease (multiple); aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 2.7), mammary gland adult (RPKM 2.5) and 10 other tissues See more
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3793395..3798984, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3743395..3748984, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
Title: LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
Marginal zone SIGN-R1(+) macrophages are essential for the maturation of germinal center B cells in the spleen.
Title: Marginal zone SIGN-R1(+) macrophages are essential for the maturation of germinal center B cells in the spleen.
Sepsis-induced DC-SIGN expression in IECs plays a significant role in regulating acute intestinal injury and systemic inflammatory response. The inhibition of DC-SIGN exhibited protective effects on sepsis-associated organ injury and systemic inflammation.
Title: DC-SIGN Expression in Intestinal Epithelial Cells Regulates Sepsis-Associated Acute Intestinal Injury Via Activating ERK1/2-NF-κB/P65 Signaling.
Study showed that SIGN-R1 participates in the recognition of influenza virus by interacting with N-linked glycans present in glycoproteins of the virion envelope.
Title: Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1.
mouse DC-SIGN shows partly overlapping similarities to human DC-SIGN; mDC-SIGN is expressed on GM-CSF cultured bone marrow-derived dendritic cells and macrophages
Title: Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity.
CD209a drives severe Th17 cell-mediated immunopathology in a helminthic disease
Title: CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology.
mDectin-1, mDectin-2, and SIGN-R1 are decorated by N-glycan structures that can be recognized by the carbohydrate recognition domain of Gal-3.
Title: Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.
M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 over-expression and elevated synthesis of IL-10, most likely through TLR4 and Raf-1 signaling pathway-dependent DC-SIGN stimulation.
Title: TLR4 and DC-SIGN receptors recognized Mycobacterium scrofulaceum promoting semi-activated phenotype on bone marrow dendritic cells.
results suggested that podocytes in lupus nephritis can exert dendritic cell-like function through their expression of DC-SIGN, which may be involved in immune and inflammatory responses of renal tissues
Title: DC-SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis.
results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after gamma-irradiation
Title: SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables carbohydrate derivative binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD209 antigen-like protein A

Names: dendritic cell-specific ICAM-3-grabbing non-integrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133238.5 → NP_573501.1 CD209 antigen-like protein A

See identical proteins and their annotated locations for NP_573501.1

Status: VALIDATED

Source sequence(s)

AY049062

Consensus CDS

CCDS22073.1

UniProtKB/Swiss-Prot

Q3TAT9, Q91ZW5, Q91ZX1

Related

ENSMUSP00000012847.2, ENSMUST00000012847.3

Conserved Domains (1) summary

cd03590
Location:108 → 230

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)