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    Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus (house mouse) ]

    Gene ID: 12287, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cacna1bprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, N type, alpha 1B subunitprovided by MGI
    Primary source
    MGI:MGI:88296
    See related
    Ensembl:ENSMUSG00000004113 AllianceGenome:MGI:88296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIII; Cav2.2; Cchn1a; alpha(1B)
    Summary
    Enables high voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; neurotransmitter secretion; and response to pain. Located in dendrite; membrane; and neuronal cell body. Part of voltage-gated calcium channel complex. Is active in presynaptic active zone. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 9.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacna1b in Genome Data Viewer
    Location:
    2 A3; 2 16.58 cM
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24493872..24653210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24603860..24763200, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Pax8 CNS1 enhancer Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice. Takahashi E, et al. Brain Res Mol Brain Res, 2004 Apr 29. PMID 15093688
    2. Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel. Mishima K, et al. PLoS One, 2019. PMID 31596895, Free PMC Article
    3. Modified sympathetic regulation in N-type calcium channel null-mouse. Murakami M, et al. Biochem Biophys Res Commun, 2007 Mar 23. PMID 17275790
    4. Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Takei T, et al. Neurosci Lett, 2003 Oct 16. PMID 12962913
    5. Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo. Nieto-Rostro M, et al. Proc Natl Acad Sci U S A, 2018 Dec 18. PMID 30487217, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-1alpha links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
      Title: Interleukin-1α links peripheral Ca(V)2.2 channel activation to rapid adaptive increases in heat sensitivity in skin.
    2. Cav2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
      Title: Ca(v)2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse.
    3. N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
      Title: N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
    4. Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
      Title: Constitutive activity of dopamine receptor type 1 (D1R) increases CaV2.2 currents in PFC neurons.
    5. Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
      Title: Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+) channel ameliorates behavioral deficits in a mouse model of Parkinson's disease.
    6. Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
      Title: Involvement of N-type Ca(2+) channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
    7. alternative splicing of Cacna1b e37a influences excitatory transmitter release and couples to complex behaviors.
      Title: Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.
    8. Co-immunoprecipitations from brain tissue is consistent with the formation of a protein complex between RB-3alpha and RB-3beta and both Cav2.2 and the related Cav2.1 calcium channel.
      Title: Interactions of Rabconnectin-3 with Cav2 calcium channels.
    9. The studies and identified +e18a-Cacna1b mRNA in deep cerebellar cells and spinal cord motor neurons and +e18a-Cacna1b is enriched in cholecystokinin-expressing interneurons.
      Title: Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.
    10. Munc13-3 regulates the density of Cav2.1 and Cav2.2 channels, alters the localization of Cav2.1, and is required for the development of tight, nanodomain coupling at parallel-fiber active zones.
      Title: Munc13-3 Is Required for the Developmental Localization of Ca(2+) Channels to Active Zones and the Nanopositioning of Ca(v)2.1 Near Release Sensors.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to testosterone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    voltage-dependent N-type calcium channel subunit alpha-1B
    Names
    brain calcium channel III
    calcium channel, L type, alpha-1 polypeptide
    calcium channel, voltage-dependent, L type, alpha 1B subunit
    calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII
    voltage-gated calcium channel subunit alpha Cav2.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042528.3 → NP_001035993.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

      See identical proteins and their annotated locations for NP_001035993.1

      Status: VALIDATED

      Source sequence(s)
      AL732525, AL732546, BX294112
      Consensus CDS
      CCDS38065.1
      UniProtKB/Swiss-Prot
      O55017, Q60609
      UniProtKB/TrEMBL
      A2AIR7
      Related
      ENSMUSP00000037416.6, ENSMUST00000041342.12
      Conserved Domains (3) summary
      pfam00520
      Location:1481 → 1710
      Ion_trans; Ion transport protein
      pfam08763
      Location:1784 → 1858
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1718 → 1782
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. NM_007579.4 → NP_031605.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732525, AL732546, BX294112
      Consensus CDS
      CCDS15739.1
      UniProtKB/TrEMBL
      A2AIR7, A2AIS0
      Related
      ENSMUSP00000063236.8, ENSMUST00000070864.14
      Conserved Domains (3) summary
      pfam00520
      Location:1476 → 1707
      Ion_trans; Ion transport protein
      pfam08763
      Location:1781 → 1819
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1715 → 1779
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24493872..24653210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497635.4 → XP_006497698.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (4) summary
      PHA03307
      Location:1884 → 2251
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:94 → 367
      Ion_trans; Ion transport protein
      pfam08763
      Location:1733 → 1807
      Ca_chan_IQ; Voltage gated calcium channel IQ domain

    2. XM_006497634.3 → XP_006497697.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1932 → 2299
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:913 → 1018
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1458 → 1707
      Ion_trans; Ion transport protein
      pfam08763
      Location:1781 → 1855
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1716 → 1769
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. XM_006497632.3 → XP_006497695.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

      UniProtKB/TrEMBL
      A2AIR7, A2AIR9
      Related
      ENSMUSP00000100003.3, ENSMUST00000102939.9
      Conserved Domains (5) summary
      PHA03307
      Location:1933 → 2300
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:914 → 1019
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1459 → 1708
      Ion_trans; Ion transport protein
      pfam08763
      Location:1782 → 1856
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1717 → 1770
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. XM_017315156.1 → XP_017170645.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1952 → 2319
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:935 → 1040
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1480 → 1727
      Ion_trans; Ion transport protein
      pfam08763
      Location:1801 → 1875
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1736 → 1789
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. XM_017315140.1 → XP_017170629.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1958 → 2325
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:935 → 1040
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1484 → 1733
      Ion_trans; Ion transport protein
      pfam08763
      Location:1807 → 1881
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1742 → 1795
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    6. XM_017315146.1 → XP_017170635.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1937 → 2304
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:914 → 1019
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1463 → 1712
      Ion_trans; Ion transport protein
      pfam08763
      Location:1786 → 1860
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1721 → 1774
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. XM_006497633.3 → XP_006497696.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1932 → 2299
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:915 → 1020
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1460 → 1707
      Ion_trans; Ion transport protein
      pfam08763
      Location:1781 → 1855
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1716 → 1769
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    8. XM_006497631.3 → XP_006497694.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1938 → 2305
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:915 → 1020
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1464 → 1713
      Ion_trans; Ion transport protein
      pfam08763
      Location:1787 → 1861
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1722 → 1775
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. XM_006497629.3 → XP_006497692.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1954 → 2321
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:935 → 1040
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1480 → 1729
      Ion_trans; Ion transport protein
      pfam08763
      Location:1803 → 1877
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1738 → 1791
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. XM_006497627.3 → XP_006497690.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1958 → 2325
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:935 → 1040
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1484 → 1733
      Ion_trans; Ion transport protein
      pfam08763
      Location:1807 → 1881
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1742 → 1795
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    11. XM_006497630.3 → XP_006497693.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1953 → 2320
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1481 → 1728
      Ion_trans; Ion transport protein
      pfam08763
      Location:1802 → 1876
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1737 → 1790
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. XM_006497628.3 → XP_006497691.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1955 → 2322
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1481 → 1730
      Ion_trans; Ion transport protein
      pfam08763
      Location:1804 → 1878
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1739 → 1792
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. XM_017315141.1 → XP_017170630.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1957 → 2324
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1485 → 1732
      Ion_trans; Ion transport protein
      pfam08763
      Location:1806 → 1880
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1741 → 1794
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    14. XM_006497626.3 → XP_006497689.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

      UniProtKB/TrEMBL
      A2AIR7
      Conserved Domains (5) summary
      PHA03307
      Location:1959 → 2326
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1485 → 1734
      Ion_trans; Ion transport protein
      pfam08763
      Location:1808 → 1882
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1743 → 1796
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    15. XM_011239014.2 → XP_011237316.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

      UniProtKB/TrEMBL
      Q3UYN6
      Conserved Domains (4) summary
      PHA03307
      Location:850 → 1217
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00520
      Location:376 → 625
      Ion_trans; Ion transport protein
      pfam08763
      Location:699 → 773
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:634 → 687
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    16. XM_006497637.5 → XP_006497700.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

      Conserved Domains (3) summary
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1485 → 1734
      Ion_trans; Ion transport protein
      pfam16905
      Location:1743 → 1756
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. XM_017315155.2 → XP_017170644.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

      Conserved Domains (3) summary
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1481 → 1728
      Ion_trans; Ion transport protein
      pfam16905
      Location:1737 → 1782
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    18. XM_006497638.4 → XP_006497701.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

      Conserved Domains (3) summary
      pfam01271
      Location:936 → 1041
      Granin; Granin (chromogranin or secretogranin)
      pfam00520
      Location:1485 → 1734
      Ion_trans; Ion transport protein
      pfam16905
      Location:1743 → 1788
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RNA

    1. XR_003950091.2 RNA Sequence

    2. XR_374052.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55017.1 GenPept UniProtKB/Swiss-Prot:O55017

    Gene LinkOut

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