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    Ergic3 ERGIC and golgi 3 [ Mus musculus (house mouse) ]

    Gene ID: 66366, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ergic3provided by MGI
    Official Full Name
    ERGIC and golgi 3provided by MGI
    Primary source
    MGI:MGI:1913616
    See related
    Ensembl:ENSMUSG00000005881 AllianceGenome:MGI:1913616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-54; D2Ucla1; NY-BR-84; Sdbcag84; 2310015B14Rik
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of intracellular protein transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Predicted to be part of retrograde transporter complex, Golgi to ER. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in cerebellum; neocortex; and spleen. Orthologous to human ERGIC3 (ERGIC and golgi 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 128.8), ovary adult (RPKM 102.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ergic3 in Genome Data Viewer
    Location:
    2 H1; 2 77.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155849948..155860199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156008028..156018279)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 5 Neighboring gene STARR-seq mESC enhancer starr_06152 Neighboring gene centrosomal protein 250 Neighboring gene predicted gene, 50621 Neighboring gene RIKEN cDNA 6430550D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9074 Neighboring gene fer-1 like family member 4 Neighboring gene AE binding protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae. Orci L, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12663859, Free PMC Article
    2. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
    3. Mapping of three members of the mouse protein disulfide isomerase family. Briquet-Laugier V, et al. Mamm Genome, 1998 Feb. PMID 9457688
    4. A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. Jiang Y, et al. J Biol Chem, 1996 May 3. PMID 8631881
    5. Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. Klingenspor M, et al. J Biol Chem, 1999 Aug 13. PMID 10438476

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans.
      Title: ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp547A2190

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retrograde transporter complex, Golgi to ER IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retrograde transporter complex, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum-Golgi intermediate compartment protein 3
    Names
    serologically defined breast cancer antigen 84
    serologically defined breast cancer antigen NY-BR-84 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356413.1 → NP_001343342.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC057130, DV662805
      Consensus CDS
      CCDS89572.1
      Related
      ENSMUSP00000086025.5, ENSMUST00000088650.11
      Conserved Domains (2) summary
      pfam07970
      Location:145 → 374
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:7 → 93
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    2. NM_001356414.1 → NP_001343343.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL833786
      Conserved Domains (2) summary
      pfam07970
      Location:145 → 368
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:7 → 97
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    3. NM_025516.5 → NP_079792.1  endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform 3

      See identical proteins and their annotated locations for NP_079792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI837012, AK050285, AL833786, DV662805
      Consensus CDS
      CCDS16959.1
      UniProtKB/Swiss-Prot
      B7ZCN9, Q6PGA7, Q9CQE7
      Related
      ENSMUSP00000006035.7, ENSMUST00000006035.13
      Conserved Domains (2) summary
      pfam07970
      Location:145 → 363
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:7 → 97
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155849948..155860199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQE7.1 GenPept UniProtKB/Swiss-Prot:Q9CQE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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