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    Spred2 sprouty-related EVH1 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 114716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spred2provided by MGI
    Official Full Name
    sprouty-related EVH1 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2150019
    See related
    Ensembl:ENSMUSG00000045671 AllianceGenome:MGI:2150019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.8), adrenal adult (RPKM 1.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Spred2 in Genome Data Viewer
    Location:
    11 A3.1; 11 12.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (19874442..19974026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (19924442..20024026)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39602 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3934 Neighboring gene STARR-seq mESC enhancer starr_28754 Neighboring gene STARR-seq mESC enhancer starr_28757 Neighboring gene STARR-seq mESC enhancer starr_28758 Neighboring gene STARR-seq mESC enhancer starr_28760 Neighboring gene STARR-positive B cell enhancer ABC_E10665 Neighboring gene STARR-seq mESC enhancer starr_28762 Neighboring gene STARR-seq mESC enhancer starr_28763 Neighboring gene STARR-seq mESC enhancer starr_28769 Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene actin related protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1412 Neighboring gene STARR-positive B cell enhancer ABC_E9359

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables stem cell factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sprouty-related, EVH1 domain-containing protein 2
    Names
    sprouty protein with EVH-1 domain 2, related sequence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033523.4NP_277058.1  sprouty-related, EVH1 domain-containing protein 2

      See identical proteins and their annotated locations for NP_277058.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645609, AL672084
      Consensus CDS
      CCDS24454.1
      UniProtKB/Swiss-Prot
      Q924S7
      UniProtKB/TrEMBL
      Q5SRF8
      Related
      ENSMUSP00000090987.6, ENSMUST00000093298.12
      Conserved Domains (2) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299397
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      19874442..19974026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514456.5XP_006514519.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:29141
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:316414
      Sprouty; Sprouty protein (Spry)
    2. XM_006514458.5XP_006514521.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0AAQ4VMS6, Q5SRF8
      Related
      ENSMUSP00000159978.1, ENSMUST00000249881.1
      Conserved Domains (2) summary
      cd10574
      Location:9121
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296394
      Sprouty; Sprouty protein (Spry)
    3. XM_036156236.1XP_036012129.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:1104
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:278383
      Sprouty; Sprouty protein (Spry)
    4. XM_006514457.5XP_006514520.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299397
      Sprouty; Sprouty protein (Spry)