Mmrn2 multimerin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmrn2provided by MGI
Official Full Name: multimerin 2provided by MGI
Primary source: MGI:MGI:2385618
See related: Ensembl:ENSMUSG00000041445 AllianceGenome:MGI:2385618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emilin3; ENDOGLYX1; EndoGlyx-1
Summary: Predicted to enable receptor ligand activity. Predicted to be an extracellular matrix structural constituent. Involved in cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of defense response to bacterium. Located in basement membrane. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 15.0), lung adult (RPKM 10.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.81 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (34097461..34126244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34375504..34404287)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multimerin-2 maintains vascular stability and permeability.
Title: Multimerin-2 maintains vascular stability and permeability.
These results reveal that CD93 is a negative regulator of the onset of astrogenesis and provide insight into therapy for psychiatric disorders.
Title: CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain.
MMRN2 as a crucial player in the regulation of EC function, neo-angiogenesis and hence tumor growth
Title: MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
Mmrn2 interacts with anthrax protective antigen.
Title: EMILINs interact with anthrax protective antigen and inhibit toxin action in vitro.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237166

NoName (e-PCR)
- UniSTS:237167

AA986839 (e-PCR)
- UniSTS:185996

PMC262405P1 (e-PCR)
- UniSTS:272314

NoName (e-PCR)
- UniSTS:492741

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of multimerin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: multimerin-2

Names: elastin microfibril interfacer 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.