Isy1 ISY1 splicing factor homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isy1provided by MGI
Official Full Name: ISY1 splicing factor homologprovided by MGI
Primary source: MGI:MGI:1923310
See related: Ensembl:ENSMUSG00000030056 AllianceGenome:MGI:1923310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5830446M03Rik
Summary: Predicted to be involved in generation of catalytic spliceosome for second transesterification step and mRNA 3'-splice site recognition. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ISY1 (ISY1 splicing factor homolog) and ISY1-RAB43 (ISY1-RAB43 readthrough). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 22.8), liver E14 (RPKM 16.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 39.13 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87795429..87815723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87818447..87838923, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI181014 (e-PCR)
- UniSTS:159536

RH136565 (e-PCR)
- UniSTS:210545

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in generation of catalytic spliceosome for second transesterification step	IBA Inferred from Biological aspect of Ancestor more info
involved_in generation of catalytic spliceosome for second transesterification step	IEA Inferred from Electronic Annotation more info
involved_in mRNA 3'-splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 1 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 1 spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of post-mRNA release spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of post-spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pre-mRNA-splicing factor ISY1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.