Nckipsd NCK interacting protein with SH3 domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nckipsdprovided by MGI
Official Full Name: NCK interacting protein with SH3 domainprovided by MGI
Primary source: MGI:MGI:1931834
See related: Ensembl:ENSMUSG00000032598 AllianceGenome:MGI:1931834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIP1; ORF1; WISH; Wasbp; AF3P21; SPIN90; WASLBP
Summary: Predicted to enable Arp2/3 complex binding activity. Involved in positive regulation of neuron projection development. Predicted to be located in glutamatergic synapse and postsynapse. Predicted to be part of COP9 signalosome. Is expressed in central nervous system and retina. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 18.3), cerebellum adult (RPKM 18.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108685515..108696044)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108808346..108818839)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPIN90 Deficiency Ameliorates Amyloid beta Accumulation by Regulating APP Trafficking in AD Model Mice.
Title: SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice.
SPIN90 depletion activates FAK/ROCK signaling, induced by Postn expression, which is critical for myofibroblastic differentiation on soft matrices mimicking the mechanical environment of a normal tissue.
Title: Downregulation of SPIN90 promotes fibroblast activation via periostin-FAK-ROCK signaling module.
Low SPIN90 expression is associated with Breast Cancer.
Title: SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression.
Data suggest that Src homology 3 (SH3) protein interacting with NcK, 90 kDa (SPIN90)plays an important role in B cell immune responses through the regulation of chemokine CXCL13-mediated B cell migration.
Title: Spin90 deficiency increases CXCL13-mediated B cell migration.
Findings show that SPIN90 modulates synaptic activity in neurons as a result of its phosphorylation.
Title: SPIN90 phosphorylation modulates spine structure and synaptic function.
DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.
Title: DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.
SPIN90 plays critical roles in controlling growth cone dynamics and neurite outgrowth during neuronal development.
Title: Control of growth cone motility and neurite outgrowth by SPIN90.
Results show that DIP/WISH binds to mammalian diaphanous and N-WASP, and functions as a scaffold protein by binding to Nck protein.
Title: DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts.
SPIN90 is a Shank1b binding partner and a key contributor to the regulation of dendritic spine morphogenesis and brain function
Title: Regulation of dendritic spine morphology by SPIN90, a novel Shank binding partner.
identification of a new interaction between Nef and diaphanous interacting protein (DIP), a recently described regulator of Rho and Rac signaling
Title: HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NCK-interacting protein with SH3 domain

Names: 54 kDa VacA-interacting protein; 90 kDa N-WASP-interacting protein; 90 kDa SH3 protein interacting with Nck; N-WASP-binding protein; SH3 adapter protein SPIN90; VIP54; WASP-interacting SH3-domain protein; Wiskott-Aldrich syndrome homolog binding protein; mDia interacting protein-1; wiskott-Aldrich syndrome protein-binding protein WISH

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030729.5 → NP_109654.2 NCK-interacting protein with SH3 domain

See identical proteins and their annotated locations for NP_109654.2

Status: VALIDATED

Source sequence(s)

AC168054

Consensus CDS

CCDS23538.1

UniProtKB/Swiss-Prot

Q3UYF3, Q68G72, Q9ESJ4

Related

ENSMUSP00000035218.8, ENSMUST00000035218.9

Conserved Domains (2) summary

cd11849
Location:1 → 53

SH3_SPIN90; Src homology 3 domain of SH3 protein interacting with Nck, 90 kDa (SPIN90)

pfam09431
Location:558 → 675

DUF2013; Protein of unknown function (DUF2013)

RNA

NR_185295.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC168054

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108685515..108696044

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511860.5 → XP_006511923.1 NCK-interacting protein with SH3 domain isoform X1

Conserved Domains (1) summary

pfam09431
Location:500 → 617

DUF2013; Protein of unknown function (DUF2013)
XM_030244729.2 → XP_030100589.1 NCK-interacting protein with SH3 domain isoform X2

Conserved Domains (1) summary

pfam09431
Location:250 → 367

DUF2013; Protein of unknown function (DUF2013)