Scd2 stearoyl-Coenzyme A desaturase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scd2provided by MGI
Official Full Name: stearoyl-Coenzyme A desaturase 2provided by MGI
Primary source: MGI:MGI:98240
See related: Ensembl:ENSMUSG00000025203 AllianceGenome:MGI:98240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: swty; Scd-2; Mir5114; mir-5114
Summary: Enables palmitoyl-CoA 9-desaturase activity and stearoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 186.3), subcutaneous fat pad adult (RPKM 170.4) and 25 other tissues See more
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Genomic context

Location:: 19 C3; 19 37.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44282115..44295303)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44293676..44306864)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages.
Title: Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages.
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - beta-catenin cascade to promote liver tumorigenesis.
Title: Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.
Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells.
Title: Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells.
SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4(+) T cells.
Title: SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4(+) T cells.
Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease.
Title: Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease.
Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity.
Title: Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity.
Exercise-induced nerve center fatigue is correlated with gene expressions of B-FABP and SCD2.
Title: [Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray].
Inhibition of adipogenesis caused by SCD2 depletion was associated with a decrease in PPAR-gamma mRNA and protein, whereas in mature adipocytes loss of SCD2 diminished PPARgamma protein levels, with little change in mRNA levels.
Title: Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells.
SCD2 is crucial in the synthesis of monounsaturated fatty acids that are required for maintaining normal epidermal permeability barrier function and biosynthesis of lipids during early skin and liver development.
Title: Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development.
Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0.
Title: Identification of mouse palmitoyl-coenzyme A Delta9-desaturase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M26270 (e-PCR)
- UniSTS:124950

Scd1 (e-PCR), detects polymorphism
- UniSTS:461929

NoName (e-PCR)
- UniSTS:237954

RH140028 (e-PCR)
- UniSTS:222110

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-CoA 9-desaturase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables stearoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in monounsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stearoyl-CoA desaturase 2

Names: Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty acid desaturase 2) (Delta(9)-desaturase 2); delta(9)-desaturase 2; fatty acid desaturase 2

NP_033154.2

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009128.2 → NP_033154.2 stearoyl-CoA desaturase 2

See identical proteins and their annotated locations for NP_033154.2

Status: VALIDATED

Source sequence(s)

AK083922, AK159413, CF168778, CJ110442, CJ242760

Consensus CDS

CCDS29848.1

UniProtKB/Swiss-Prot

P13011, Q8BH96

Related

ENSMUSP00000026221.6, ENSMUST00000026221.7

Conserved Domains (1) summary

cd03505
Location:96 → 336

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...