Ube2r2 ubiquitin-conjugating enzyme E2R 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2r2provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2R 2provided by MGI
Primary source: MGI:MGI:1914865
See related: Ensembl:ENSMUSG00000036241 AllianceGenome:MGI:1914865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubc3b; Cdc34b; 1200003M11Rik
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination; protein monoubiquitination; and ubiquitin-dependent protein catabolic process. Orthologous to human UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 43.4), bladder adult (RPKM 39.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.02 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41136021..41193370)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41136021..41193370)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ube2r2 (e-PCR), detects polymorphism
- UniSTS:527597

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 R2

Names: E2 ubiquitin-conjugating enzyme R2; E2-CDC34B; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme E2-CDC34B; ubiquitin-protein ligase R2

NP_080551.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026275.4 → NP_080551.1 ubiquitin-conjugating enzyme E2 R2

See identical proteins and their annotated locations for NP_080551.1

Status: PROVISIONAL

Source sequence(s)

AL807823, AL954379

Consensus CDS

CCDS18057.1

UniProtKB/Swiss-Prot

Q6ZWZ2, Q8BW18, Q8VDE5

Related

ENSMUSP00000038813.4, ENSMUST00000040008.4

Conserved Domains (1) summary

cd00195
Location:11 → 169

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...