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    Tnpo1 transportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 238799, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tnpo1provided by MGI
    Official Full Name
    transportin 1provided by MGI
    Primary source
    MGI:MGI:2681523
    See related
    Ensembl:ENSMUSG00000009470 AllianceGenome:MGI:2681523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP; TRN; IPO2; MIP1; Kpnb2; D13Ertd688e
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnpo1 in Genome Data Viewer
    Location:
    13 D1; 13 52.24 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98975527..99062851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98839019..98926384, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene FCH domain only 2 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:99660904-99661128 Neighboring gene ribosomal protein L27A, pseudogene 4 Neighboring gene predicted gene, 52051 Neighboring gene predicted gene, 35215 Neighboring gene predicted gene, 47052

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock. Sato M, et al. J Comp Neurol, 2011 Jun 15. PMID 21452213
    2. Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2. Björkblom B, et al. Mol Cell Biol, 2014 Aug. PMID 24912681, Free PMC Article
    3. Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Di Benedetto A, et al. Proc Natl Acad Sci U S A, 2014 Nov 18. PMID 25378700, Free PMC Article
    4. A role for Rab23 in the trafficking of Kif17 to the primary cilium. Lim YS, et al. J Cell Sci, 2015 Aug 15. PMID 26136363
    5. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. van der Giessen K, et al. Mol Biol Cell, 2007 Jul. PMID 17475777, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-immunoprecipitation and affinity-binding studies revealed that Rab23 exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 for its ciliary transport
      Title: A role for Rab23 in the trafficking of Kif17 to the primary cilium.
    2. Association with Tnpo1 is necessary for Oxtr nuclear localization. This is required for Oxt-induced osteoblast differentiation. osteoblast differentiation.
      Title: Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor.
    3. DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
      Title: Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2.
    4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.
      Title: Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.
    5. Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
      Title: Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transportin-1
    Names
    importin beta-2
    karyopherin (importin) beta 2
    karyopherin beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048267.2 → NP_001041732.1  transportin-1 isoform 2

      See identical proteins and their annotated locations for NP_001041732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC129085, AC154849
      Consensus CDS
      CCDS36760.1
      UniProtKB/TrEMBL
      Q3TKD0
      Related
      ENSMUSP00000105026.3, ENSMUST00000109399.9
      Conserved Domains (2) summary
      COG5215
      Location:24 → 759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95 → 116
      HEAT; HEAT repeat [structural motif]

    2. NM_001426412.1 → NP_001413341.1  transportin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849

    3. NM_001426413.1 → NP_001413342.1  transportin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849

    4. NM_001426414.1 → NP_001413343.1  transportin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849
      Related
      ENSMUSP00000136917.2, ENSMUST00000179301.8

    5. NM_001426415.1 → NP_001413344.1  transportin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849

    6. NM_178716.4 → NP_848831.2  transportin-1 isoform 1

      See identical proteins and their annotated locations for NP_848831.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC129085, AC154849
      Consensus CDS
      CCDS26717.2
      UniProtKB/Swiss-Prot
      Q8BFY9, Q8C0S3, Q8K2E7
      UniProtKB/TrEMBL
      Q3TKD0
      Related
      ENSMUSP00000105028.2, ENSMUST00000109401.8
      Conserved Domains (2) summary
      COG5215
      Location:32 → 767
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103 → 124
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_189735.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98975527..99062851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFY9.2 GenPept UniProtKB/Swiss-Prot:Q8BFY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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