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    Ivns1abp influenza virus NS1A binding protein [ Mus musculus (house mouse) ]

    Gene ID: 117198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ivns1abpprovided by MGI
    Official Full Name
    influenza virus NS1A binding proteinprovided by MGI
    Primary source
    MGI:MGI:2152389
    See related
    Ensembl:ENSMUSG00000023150 AllianceGenome:MGI:2152389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ND1; NS-1; Nd1-L; Nd1-S; NS1-BP; HSPC068; mKIAA0850; 1190004M08Rik; 1700126I16Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 79.1), CNS E11.5 (RPKM 71.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ivns1abp in Genome Data Viewer
    Location:
    1 G1; 1 64.06 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151220237..151240196)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151344486..151364445)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47996 Neighboring gene STARR-positive B cell enhancer ABC_E4356 Neighboring gene STARR-seq mESC enhancer starr_02612 Neighboring gene predicted gene, 46162 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:153134717-153134870 Neighboring gene STARR-seq mESC enhancer starr_02614 Neighboring gene STARR-seq mESC enhancer starr_02615 Neighboring gene predicted gene 10138 Neighboring gene STARR-positive B cell enhancer ABC_E3312 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153191350-153191651 Neighboring gene STARR-positive B cell enhancer ABC_E3313 Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene tRNA methyltransferase 1 like Neighboring gene microRNA 7682

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1. Donátová K, et al. Int J Mol Sci, 2024 Feb 20. PMID 38473707, Free PMC Article
    2. Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors. Lin Y, et al. DNA Cell Biol, 2018 Oct. PMID 30124330
    3. Nd1, a novel murine Kelch family protein, may play the role of a housekeeping gene. Kang M, et al. Biochim Biophys Acta, 2001 Jun 28. PMID 11418182
    4. Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts. Inoue A, et al. DNA Cell Biol, 2005 Jan. PMID 15684717
    5. Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments. Sasagawa K, et al. J Biol Chem, 2002 Nov 15. PMID 12213805

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
      Title: Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1.
    2. Overexpression of short variant form of new Kelch family protein ND1 leads to erythroid and megakaryocyte dysplasia by targeting megakaryocyte-erythroid progenitors.
      Title: Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors.
    3. Nd1-L is involved in invasion and metastasis of cancer cells by regulating the actin cytoskeleton and Rho family proteins.
      Title: A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism.
    4. Nd1-S may play a role in cell cycle progression in the nucleus.
      Title: Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts.
    5. Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton
      Title: Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments.
    6. Plays a critical role in protecting the heart from doxorubicin-induced cardiomyopathy.
      Title: Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    influenza virus NS1A-binding protein homolog
    Names
    ND1-L2
    NS1-binding protein homolog
    kelch family protein Nd1
    kelch family protein Nd1-L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039511.1 → NP_001034600.1  influenza virus NS1A-binding protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001034600.1

      Status: VALIDATED

      Source sequence(s)
      AC115060, AK007291, AL355706
      Consensus CDS
      CCDS35735.1
      UniProtKB/Swiss-Prot
      Q920Q8
      Related
      ENSMUSP00000107518.4, ENSMUST00000111887.10
      Conserved Domains (2) summary
      cd18306
      Location:14 → 137
      BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
      cd18502
      Location:129 → 221
      BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

    2. NM_001039512.1 → NP_001034601.1  influenza virus NS1A-binding protein homolog isoform 3

      See identical proteins and their annotated locations for NP_001034601.1

      Status: VALIDATED

      Source sequence(s)
      AC115060, AK144835, AL355706
      Consensus CDS
      CCDS15358.1
      UniProtKB/Swiss-Prot
      Q920Q8
      Related
      ENSMUSP00000095150.2, ENSMUST00000097543.8
      Conserved Domains (6) summary
      smart00612
      Location:472 → 517
      Kelch; Kelch domain
      PHA03098
      Location:23 → 596
      PHA03098; kelch-like protein; Provisional
      cd14735
      Location:129 → 181
      BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam01344
      Location:553 → 593
      Kelch_1; Kelch motif

    3. NM_001359262.1 → NP_001346191.1  influenza virus NS1A-binding protein homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165946
      Conserved Domains (3) summary
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:553 → 593
      Kelch_1; Kelch motif
      cl28614
      Location:3 → 549
      BTB; Broad-Complex, Tramtrack and Bric a brac

    4. NM_001359263.1 → NP_001346192.1  influenza virus NS1A-binding protein homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC165946
      UniProtKB/TrEMBL
      Q06BK5
      Conserved Domains (3) summary
      smart00612
      Location:88 → 134
      Kelch; Kelch domain
      PHA03098
      Location:136 → 357
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:221 → 264
      Kelch; KELCH repeat [structural motif]

    5. NM_054102.2 → NP_473443.2  influenza virus NS1A-binding protein homolog isoform 2

      See identical proteins and their annotated locations for NP_473443.2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AK146494, AL355706
      Consensus CDS
      CCDS15359.1
      UniProtKB/Swiss-Prot
      Q06BK6, Q3TXI1, Q3UJE3, Q3UJS1, Q3UKH9, Q3UMK9, Q6ZQ34, Q920Q8, Q99KN0, Q9D978
      Related
      ENSMUSP00000023918.7, ENSMUST00000023918.13
      Conserved Domains (3) summary
      sd00038
      Location:502 → 545
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:595 → 635
      Kelch_1; Kelch motif
      cl28614
      Location:23 → 591
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      151220237..151240196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529089.4 → XP_006529152.1  influenza virus NS1A-binding protein homolog isoform X1

      Conserved Domains (3) summary
      smart00612
      Location:209 → 255
      Kelch; Kelch domain
      PHA03098
      Location:257 → 478
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:342 → 385
      Kelch; KELCH repeat [structural motif]

    2. XM_030243144.1 → XP_030099004.1  influenza virus NS1A-binding protein homolog isoform X1

      Conserved Domains (3) summary
      smart00612
      Location:209 → 255
      Kelch; Kelch domain
      PHA03098
      Location:257 → 478
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:342 → 385
      Kelch; KELCH repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028582.2: Suppressed sequence

      Description
      NM_028582.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920Q8.2 GenPept UniProtKB/Swiss-Prot:Q920Q8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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