Nop2 NOP2 nucleolar protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nop2provided by MGI
Official Full Name: NOP2 nucleolar proteinprovided by MGI
Primary source: MGI:MGI:107891
See related: Ensembl:ENSMUSG00000038279 AllianceGenome:MGI:107891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nol1; 120kDa; A530002O17
Summary: Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and tooth. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 16.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 59.32 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125108829..125121716)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125131883..125144753)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N[4]-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst.
Title: N(4)-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst.
The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals.
Title: The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals.
results demonstrate that Nop2 is an essential gene for blastocyst formation, and is required for RNA processing and/or stability in vivo during preimplantation embryo development in the mouse.
Title: Nop2 is required for mammalian preimplantation development.
Findings suggest a newly discovered role of Nop2 in both mature neurons and in cells possibly involved in the regeneration of nervous tissue
Title: Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain.
Inappropriate expression of the p120 gene can result in aberrant neutrophil maturation.
Title: p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235555

RH124259 (e-PCR)
- UniSTS:161081

D6Ertd380e (e-PCR), detects polymorphism
- UniSTS:167483

Nol1 (e-PCR), detects polymorphism
- UniSTS:144037

AA963793 (e-PCR)
- UniSTS:243386

RH64827 (e-PCR)
- UniSTS:78038

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA (cytosine-C5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (cytosine-C5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables rRNA (cytosine-C5-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal large subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 28S rRNA (cytosine-C(5))-methyltransferase; probable 28S rRNA (cytosine-C(5))-methyltransferase

Names: NOP2 nucleolar protein homolog; nucleolar protein 1, 120 kDa; nucleolar protein 2 homolog; proliferating-cell nucleolar antigen p120; proliferation-associated nucleolar protein p120; putative ribosomal RNA methyltransferase NOP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138747.2 → NP_620086.2 28S rRNA (cytosine-C(5))-methyltransferase

Status: VALIDATED

Source sequence(s)

AI325393, AK079914, BY244994

Consensus CDS

CCDS51912.1

UniProtKB/Swiss-Prot

Q3U4W9, Q922K7

UniProtKB/TrEMBL

E9QN31

Related

ENSMUSP00000047123.9, ENSMUST00000044200.11

Conserved Domains (2) summary

TIGR00446
Location:297 → 571

nop2p; NOL1/NOP2/sun family putative RNA methylase

PHA03247
Location:577 → 794

PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

125108829..125121716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255097.2 → XP_030110957.1 probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X1

UniProtKB/Swiss-Prot

Q3U4W9, Q922K7

UniProtKB/TrEMBL

E9QN31

Conserved Domains (2) summary

TIGR00446
Location:297 → 571

nop2p; NOL1/NOP2/sun family putative RNA methylase

PHA03247
Location:577 → 794

PHA03247; large tegument protein UL36; Provisional