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    Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 106952, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arap3provided by MGI
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by MGI
    Primary source
    MGI:MGI:2147274
    See related
    Ensembl:ENSMUSG00000024451 AllianceGenome:MGI:2147274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drag1; Centd3; cnt-d3; E030006K04Rik
    Summary
    This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in lung adult (RPKM 62.4), subcutaneous fat pad adult (RPKM 16.7) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arap3 in Genome Data Viewer
    Location:
    18 B3; 18 19.85 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38105676..38132583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37972623..37999531, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT-like 2 Neighboring gene microRNA 6981 Neighboring gene microRNA 6980 Neighboring gene predicted gene, 30093 Neighboring gene predicted gene, 41701 Neighboring gene STARR-seq mESC enhancer starr_44342 Neighboring gene predicted gene, 30188 Neighboring gene STARR-seq mESC enhancer starr_44344 Neighboring gene predicted gene, 30142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARAP3 functions in hematopoietic stem cells. Song Y, et al. PLoS One, 2014. PMID 25542002, Free PMC Article
    2. Identification of specific gene modules in mouse lung tissue exposed to cigarette smoke. Xing YH, et al. Asian Pac J Cancer Prev, 2015. PMID 26028081
    3. ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils. Chu JY, et al. J Pathol, 2024 Jul. PMID 38734878
    4. The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. Gambardella L, et al. Blood, 2011 Jul 28. PMID 21490342
    5. A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites. McCormick B, et al. J Immunol, 2019 Sep 15. PMID 31427445, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils.
      Title: ARAP3 protects from excessive formylated peptide-induced microvascular leakage by acting on endothelial cells and neutrophils.
    2. Deletion of Arap3 in osteoblasts and mesenchymal stromal cells using Prx1-Cre resulted in no discernable phenotypes in hematopoietic development or hematopoietic stem cells homeostasis in adult mice.
      Title: ARAP3 functions in hematopoietic stem cells.
    3. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.
      Title: Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.
    4. We report here the first characterization of the role of ARAP3 in murine neutrophils
      Title: The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
    5. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
      Title: PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
    6. the Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor
      Title: Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
    7. ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading
      Title: ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4097

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Names
    ARF-GAP, RHO-GAP, ankyrin repeat and pleckstrin homology domains-containing protein 3
    centaurin, delta 3
    dual-specificity Rho- and Arf-GTPase activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205336.2 → NP_001192265.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC121886, AC129315
      Consensus CDS
      CCDS89225.1
      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Related
      ENSMUSP00000157868.2, ENSMUST00000237272.2
      Conserved Domains (8) summary
      cd04385
      Location:827 → 1002
      RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
      cd13253
      Location:206 → 298
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:313 → 396
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1131 → 1247
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00169
      Location:205 → 296
      PH; PH domain
      pfam00788
      Location:1035 → 1128
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:407 → 523
      ArfGap; Putative GTPase activating protein for Arf
      cl17171
      Location:592 → 704
      PH-like; Pleckstrin homology-like domain

    2. NM_139206.3 → NP_631945.2  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_631945.2

      Status: REVIEWED

      Source sequence(s)
      AC121886, AC129315
      Consensus CDS
      CCDS29196.1
      UniProtKB/Swiss-Prot
      E9QMK7, Q5DTN4, Q6NVF1, Q8R5G6, Q8R5G7
      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Related
      ENSMUSP00000035662.8, ENSMUST00000042944.9
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1471 → 1537
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 311
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:905 → 1080
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:284 → 376
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:391 → 474
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1209 → 1325
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:484 → 599
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:670 → 782
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1112 → 1209
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      38105676..38132583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525492.4 → XP_006525555.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006525555.1

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (9) summary
      PLN02983
      Location:1394 → 1460
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:3 → 234
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:828 → 1003
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:207 → 299
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:314 → 397
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1132 → 1248
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:407 → 522
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:593 → 705
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1035 → 1132
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_006525488.4 → XP_006525551.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006525551.1

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1472 → 1538
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 312
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:906 → 1081
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1210 → 1326
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:671 → 783
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1113 → 1210
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_036160919.1 → XP_036016812.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (9) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:905 → 1080
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:284 → 376
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:391 → 474
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1209 → 1325
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:484 → 599
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      NF033838
      Location:81 → 150
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl17171
      Location:670 → 782
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1112 → 1209
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_006525489.3 → XP_006525552.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006525552.1

      UniProtKB/Swiss-Prot
      E9QMK7, Q5DTN4, Q6NVF1, Q8R5G6, Q8R5G7
      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1471 → 1537
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 311
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:905 → 1080
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:284 → 376
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:391 → 474
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1209 → 1325
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:484 → 599
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:670 → 782
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1112 → 1209
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_006525491.3 → XP_006525554.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      See identical proteins and their annotated locations for XP_006525554.1

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (9) summary
      PLN02983
      Location:1394 → 1460
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:3 → 234
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:828 → 1003
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:207 → 299
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:314 → 397
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1132 → 1248
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:407 → 522
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:593 → 705
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1035 → 1132
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. XM_006525490.1 → XP_006525553.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1459 → 1525
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 312
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:906 → 1081
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1210 → 1326
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:671 → 783
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1113 → 1210
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    7. XM_006525486.1 → XP_006525549.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006525549.1

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1472 → 1538
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 312
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:906 → 1081
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1210 → 1326
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:671 → 783
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1113 → 1210
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    8. XM_036160921.1 → XP_036016814.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (9) summary
      PHA03247
      Location:3 → 233
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:827 → 1002
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:206 → 298
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:313 → 396
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1131 → 1247
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:406 → 521
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      NF033838
      Location:3 → 72
      PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
      cl17171
      Location:592 → 704
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1034 → 1131
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    9. XM_030250262.2 → XP_030106122.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (9) summary
      PLN02983
      Location:1394 → 1460
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:3 → 234
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:828 → 1003
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:207 → 299
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:314 → 397
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1132 → 1248
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:407 → 522
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:593 → 705
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1035 → 1132
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    10. XM_006525487.5 → XP_006525550.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006525550.1

      UniProtKB/TrEMBL
      A0A2X0TVQ3
      Conserved Domains (10) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      PLN02983
      Location:1472 → 1538
      PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
      PHA03247
      Location:81 → 312
      PHA03247; large tegument protein UL36; Provisional
      cd04385
      Location:906 → 1081
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1210 → 1326
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:671 → 783
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1113 → 1210
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_003952486.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5G7.3 GenPept UniProtKB/Swiss-Prot:Q8R5G7

    Gene LinkOut

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