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    Foxd1 forkhead box D1 [ Mus musculus (house mouse) ]

    Gene ID: 15229, updated on 27-Nov-2024

    Summary

    Official Symbol
    Foxd1provided by MGI
    Official Full Name
    forkhead box D1provided by MGI
    Primary source
    MGI:MGI:1347463
    See related
    Ensembl:ENSMUSG00000078302 AllianceGenome:MGI:1347463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BF-2; Hfh10; FREAC4; Hfhbf2
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance and branching involved in ureteric bud morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Foxd1 in Genome Data Viewer
    Location:
    13 D1; 13 51.96 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98490753..98493213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98354245..98356705)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene basic transcription factor 3 Neighboring gene predicted gene 9828 Neighboring gene STARR-seq mESC enhancer starr_35419 Neighboring gene STARR-seq mESC enhancer starr_35420 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_35422 Neighboring gene RIKEN cDNA 2310005E17 gene Neighboring gene predicted gene, 46437 Neighboring gene predicted gene, 52050

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dichotomous subdivision of terminal units involved in ureteric bud branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in luteinizing hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric capsule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric capsule specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric nephron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nephrogenic mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pattern specification involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    forkhead box protein D1
    Names
    FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4)
    FREAC-4
    HFH-BF-2
    HNF-3/forkhead homolog, brain factor 2
    brain factor 2
    forkhead-related protein FKHL8
    forkhead-related transcription factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008242.2NP_032268.2  forkhead box protein D1

      See identical proteins and their annotated locations for NP_032268.2

      Status: VALIDATED

      Source sequence(s)
      AK132390, AK142034
      Consensus CDS
      CCDS36759.1
      UniProtKB/Swiss-Prot
      Q3UQW8, Q61345
      Related
      ENSMUSP00000100725.4, ENSMUST00000105098.6
      Conserved Domains (1) summary
      pfam00250
      Location:130216
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98490753..98493213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)