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    Mrpl12 mitochondrial ribosomal protein L12 [ Mus musculus (house mouse) ]

    Gene ID: 56282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl12provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L12provided by MGI
    Primary source
    MGI:MGI:1926273
    See related
    Ensembl:ENSMUSG00000039640 AllianceGenome:MGI:1926273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L12mt; Rpml12; MRP-L12; 0610034O11Rik; 1500031N16Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial transcription; positive regulation of DNA-templated transcription; and translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 45. Orthologous to human MRPL12 (mitochondrial ribosomal protein L12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 210.7), adrenal adult (RPKM 180.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl12 in Genome Data Viewer
    Location:
    11 E2; 11 84.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120375463..120379580)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120484637..120488754)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 137 Neighboring gene STARR-positive B cell enhancer ABC_E260 Neighboring gene ADP-ribosylation factor-like 16 Neighboring gene HGF-regulated tyrosine kinase substrate Neighboring gene solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 Neighboring gene predicted gene, 39490

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells. Ji X, et al. iScience, 2023 May 19. PMID 37182101, Free PMC Article
    2. Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. Nouws J, et al. J Biol Chem, 2016 Jan 8. PMID 26586915, Free PMC Article
    3. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Graack HR, et al. Biochemistry, 1999 Dec 14. PMID 10600119
    4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knock-down of MRPL12 by RNA interference results in instability of POLRMT.
      Title: Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein bL12m
    Names
    39S ribosomal protein L12, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027204.3 → NP_081480.2  large ribosomal subunit protein bL12m precursor

      See identical proteins and their annotated locations for NP_081480.2

      Status: VALIDATED

      Source sequence(s)
      AK134816, BQ032019
      Consensus CDS
      CCDS25737.1
      UniProtKB/Swiss-Prot
      B1ATZ3, Q3TKJ3, Q99JS8, Q9DB15
      Related
      ENSMUSP00000044417.8, ENSMUST00000043627.8
      Conserved Domains (2) summary
      cd00387
      Location:63 → 200
      Ribosomal_L7_L12; Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of ...
      COG0222
      Location:64 → 201
      RplL; Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120375463..120379580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB15.2 GenPept UniProtKB/Swiss-Prot:Q9DB15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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