Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufa6provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit A6provided by MGI
Primary source: MGI:MGI:1914380
See related: Ensembl:ENSMUSG00000022450 AllianceGenome:MGI:1914380
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 14kDa; 2700038D15Rik; B230217P19Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 198.9), kidney adult (RPKM 184.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.56 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82234342..82238438, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82350139..82354291, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufa6 (e-PCR), detects polymorphism
- UniSTS:546887

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Names: CI-B14; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14); NADH-ubiquinone oxidoreductase B14 subunit; complex I-B14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025987.4 → NP_080263.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

See identical proteins and their annotated locations for NP_080263.1

Status: VALIDATED

Source sequence(s)

AC104325

Consensus CDS

CCDS27689.1

UniProtKB/Swiss-Prot

Q9CQZ5

Related

ENSMUSP00000023085.6, ENSMUST00000023085.7

Conserved Domains (1) summary

cd20266
Location:28 → 102

Complex1_LYR_NDUFA6_LYRM6; LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins