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    Rbmxl1 RNA binding motif protein, X-linked like-1 [ Mus musculus (house mouse) ]

    Gene ID: 19656, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbmxl1provided by MGI
    Official Full Name
    RNA binding motif protein, X-linked like-1provided by MGI
    Primary source
    MGI:MGI:1343045
    See related
    Ensembl:ENSMUSG00000037070 AllianceGenome:MGI:1343045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbmx; Hnrpg; Rbmxrt
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human RBMXL1 (RBMX like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 47.6), CNS E14 (RPKM 36.5) and 25 other tissues See more
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    Genomic context

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    See Rbmxl1 in Genome Data Viewer
    Location:
    8 C1; 8 37.04 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79231898..79235557, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (78505269..78508928, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21984 Neighboring gene POU domain, class 4, transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_21987 Neighboring gene predicted gene 2225 Neighboring gene STARR-seq mESC enhancer starr_21988 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 7 Neighboring gene STARR-seq mESC enhancer starr_21992 Neighboring gene STARR-seq mESC enhancer starr_21994 Neighboring gene STARR-seq mESC enhancer starr_21995 Neighboring gene ribosomal protein L28 pseudogene Neighboring gene predicted gene, 39203

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of mammalian HNRPG and its relationship with the putative azoospermia factor RBM. Delbridge ML, et al. Mamm Genome, 1998 Feb. PMID 9457683
    2. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Mazeyrat S, et al. Nat Genet, 1999 Jul. PMID 10391207
    3. RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. Takemoto T, et al. FEBS Lett, 2007 Jan 23. PMID 17188681
    4. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. Omura Y, et al. BMB Rep, 2009 Apr 30. PMID 19403048
    5. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. Colwill K, et al. EMBO J, 1996 Jan 15. PMID 8617202, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102184

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of supraspliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding motif protein, X-linked-like-1
    Names
    RNA binding motif protein, X chromosome retrogene
    RNA-binding motif protein, X chromosome
    heterogeneous nuclear ribonucleoprotein G (hnRNP G)
    heterogeneous nuclear ribonucleoprotein G-like 1
    hnRNP G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252089.1 → NP_001239018.1  RNA binding motif protein, X-linked-like-1

      See identical proteins and their annotated locations for NP_001239018.1

      Status: VALIDATED

      Source sequence(s)
      AK041927, BC089350, BY262810
      Consensus CDS
      CCDS22430.1
      UniProtKB/Swiss-Prot
      O35479, Q91VM5
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Related
      ENSMUSP00000147384.2, ENSMUST00000211719.2
      Conserved Domains (2) summary
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    2. NM_001358974.1 → NP_001345903.1  RNA binding motif protein, X-linked-like-1

      Status: VALIDATED

      Source sequence(s)
      AC101757
      Consensus CDS
      CCDS22430.1
      UniProtKB/Swiss-Prot
      O35479, Q91VM5
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Conserved Domains (2) summary
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    3. NM_001358975.1 → NP_001345904.1  RNA binding motif protein, X-linked-like-1

      Status: VALIDATED

      Source sequence(s)
      AC101757
      Consensus CDS
      CCDS22430.1
      UniProtKB/Swiss-Prot
      O35479, Q91VM5
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Conserved Domains (2) summary
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    4. NM_009033.2 → NP_033059.2  RNA binding motif protein, X-linked-like-1

      See identical proteins and their annotated locations for NP_033059.2

      Status: VALIDATED

      Source sequence(s)
      BC089350, BY262810
      Consensus CDS
      CCDS22430.1
      UniProtKB/Swiss-Prot
      O35479, Q91VM5
      UniProtKB/TrEMBL
      A0A2I3BRL8
      Related
      ENSMUSP00000048153.8, ENSMUST00000049245.10
      Conserved Domains (2) summary
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      79231898..79235557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VM5.1 GenPept UniProtKB/Swiss-Prot:Q91VM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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