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    Kyat3 kynurenine aminotransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 229905, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kyat3provided by MGI
    Official Full Name
    kynurenine aminotransferase 3provided by MGI
    Primary source
    MGI:MGI:2677849
    See related
    Ensembl:ENSMUSG00000040213 AllianceGenome:MGI:2677849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kat3; Ccbl2; KATIII
    Summary
    Enables kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; and protein homodimerization activity. Involved in 2-oxoglutarate metabolic process and kynurenine metabolic process. Located in mitochondrion. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E18 (RPKM 19.4), liver adult (RPKM 18.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kyat3 in Genome Data Viewer
    Location:
    3 H1; 3 66.69 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142406780..142450672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142701019..142744911)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_09160 Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1270 Neighboring gene STARR-seq mESC enhancer starr_09161 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142371757-142372058 Neighboring gene STARR-seq mESC enhancer starr_09162 Neighboring gene STARR-positive B cell enhancer ABC_E6141 Neighboring gene STARR-seq mESC enhancer starr_09163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:142427870-142428053 Neighboring gene general transcription factor IIB Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene protein kinase N2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation. Poku EK, et al. Curr Mol Pharmacol, 2024. PMID 37594155
    2. Biochemical and structural properties of mouse kynurenine aminotransferase III. Han Q, et al. Mol Cell Biol, 2009 Feb. PMID 19029248, Free PMC Article
    3. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain. Lipinski M, et al. Nat Commun, 2020 May 22. PMID 32444594, Free PMC Article
    4. Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine. Pinto JT, et al. J Biol Chem, 2014 Nov 7. PMID 25231977, Free PMC Article
    5. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. Han Q, et al. BMC Biochem, 2010 May 19. PMID 20482848, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation.
      Title: Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation.
    2. KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain.
      Title: KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain.
    3. KAT III inhibited by equimolar methionine and half-life is 3.9 minutes at 65 degree C.
      Title: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
    4. The biochemical and structural properties of mouse KAT III (mKAT III) were determined.
      Title: Biochemical and structural properties of mouse kynurenine aminotransferase III.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • C430041M20

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 3
    Names
    cysteine conjugate-beta lyase 2
    cysteine-S-conjugate beta-lyase 2
    kynurenine aminotransferase III
    kynurenine--glyoxylate transaminase
    kynurenine--oxoglutarate transaminase III
    NP_001280489.1
    NP_776124.1
    XP_006501494.1
    XP_011238416.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293560.1 → NP_001280489.1  kynurenine--oxoglutarate transaminase 3 isoform 1

      See identical proteins and their annotated locations for NP_001280489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC115865, AK049569, AK145623
      Consensus CDS
      CCDS80040.1
      UniProtKB/Swiss-Prot
      Q71RI9, Q8BJ84
      Related
      ENSMUSP00000101825.2, ENSMUST00000106218.8
      Conserved Domains (2) summary
      cd00609
      Location:67 → 449
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK07777
      Location:45 → 450
      PRK07777; aminotransferase; Validated

    2. NM_173763.4 → NP_776124.1  kynurenine--oxoglutarate transaminase 3 isoform 2

      See identical proteins and their annotated locations for NP_776124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in a 5' exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC115865, AK049569, AK145623
      Consensus CDS
      CCDS17881.1
      UniProtKB/Swiss-Prot
      Q71RI9
      Related
      ENSMUSP00000041675.5, ENSMUST00000044392.11
      Conserved Domains (1) summary
      PRK07777
      Location:10 → 415
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      142406780..142450672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501431.3 → XP_006501494.1  kynurenine--oxoglutarate transaminase 3 isoform X1

      See identical proteins and their annotated locations for XP_006501494.1

      UniProtKB/Swiss-Prot
      Q71RI9
      Conserved Domains (1) summary
      PRK07777
      Location:10 → 415
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    2. XM_011240114.4 → XP_011238416.1  kynurenine--oxoglutarate transaminase 3 isoform X1

      See identical proteins and their annotated locations for XP_011238416.1

      UniProtKB/Swiss-Prot
      Q71RI9
      Conserved Domains (1) summary
      PRK07777
      Location:10 → 415
      PRK07777; putative succinyldiaminopimelate transaminase DapC
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q71RI9.1 GenPept UniProtKB/Swiss-Prot:Q71RI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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