Rgs11 regulator of G-protein signaling 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs11provided by MGI
Official Full Name: regulator of G-protein signaling 11provided by MGI
Primary source: MGI:MGI:1354739
See related: Ensembl:ENSMUSG00000024186 AllianceGenome:MGI:1354739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G-protein beta-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in dendrite terminus. Is active in cell tip and dendrite. Is expressed in several structures, including lower jaw molar; metanephros; nervous system; pancreas; and sensory organ epithelium. Orthologous to human RGS11 (regulator of G protein signaling 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 27.8), ovary adult (RPKM 17.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.07 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26421500..26430295)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26202527..26211324)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS7 and RGS11 are the key GTPase accelerating proteins in the mGluR6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses.
Title: Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
Title: Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
RGS11 staining is present in dendritic tips of rod ON-retinal bipolar cell and cone ON-retinal bipolar cell. Genetic disruption of RGS11 produced delays in the ON-BPC-derived electroretinogram b-wave, but no changes in the photoreceptor-derived a-wave.
Title: Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling.
Identification and characterization of alternatively spliced murine Rgs11 isoforms: genomic structure and gene analysis
Title: Identification and characterization of alternatively spliced murine Rgs11 isoforms: genomic structure and gene analysis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126298 (e-PCR)
- UniSTS:163006

Rgs11 (e-PCR), detects polymorphism
- UniSTS:525510

AF061934 (e-PCR)
- UniSTS:163582

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081069.3 → NP_001074538.1 regulator of G-protein signaling 11

See identical proteins and their annotated locations for NP_001074538.1

Status: VALIDATED

Source sequence(s)

AC126438

Consensus CDS

CCDS37511.1

UniProtKB/TrEMBL

E9QNN3, G3X8W6

Related

ENSMUSP00000025020.6, ENSMUST00000025020.6

Conserved Domains (3) summary

smart00224
Location:224 → 284

GGL; G protein gamma subunit-like motifs

cd04450
Location:26 → 113

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

cl02565
Location:295 → 420

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26421500..26430295

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249893.2 → XP_030105753.1 regulator of G-protein signaling 11 isoform X1

Related

ENSMUST00000147220.8

Conserved Domains (3) summary

smart00224
Location:56 → 116

GGL; G protein gamma subunit-like motifs

pfam18148
Location:3 → 41

RGS_DHEX; Regulator of G-protein signalling DHEX domain

cl02565
Location:127 → 252

RGS; Regulator of G protein signaling (RGS) domain superfamily