Akp3 alkaline phosphatase 3, intestine, not Mn requiring [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akp3provided by MGI
Official Full Name: alkaline phosphatase 3, intestine, not Mn requiringprovided by MGI
Primary source: MGI:MGI:87984
See related: Ensembl:ENSMUSG00000036500 AllianceGenome:MGI:87984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAP; dIAP; Akp-3
Summary: Predicted to enable alkaline phosphatase activity; metal ion binding activity; and protease binding activity. Acts upstream of or within neural tube development; neurogenesis; and post-anal tail morphogenesis. Located in brush border. Is expressed in duodenum; intestine; and jejunum. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 1624.4) and small intestine adult (RPKM 1516.2) See more
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Genomic context

Location:: 1 C5; 1 44.06 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87052676..87056450)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87124954..87128728)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for intestinal alkaline phosphatase in preventing liver fibrosis.
Title: A role for intestinal alkaline phosphatase in preventing liver fibrosis.
data do not support a functional role of AKP3 in adipose tissue development, or insulin sensitivity
Title: Adiposity and metabolic health in mice deficient in intestinal alkaline phosphatase.
intestinal Akp3 deletion affects Na+-dependent Pi transport in the small intestine. In the adenine-induced renal failure model, Akp3 is predicted to be a factor contributing to suppression of the plasma Pi concentration.
Title: A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis.
Authors found that Akp3(-/-) mice acquired lipopolysaccharide tolerance during postweaning development, suggesting that Akp3 plays an important role in immune education.
Title: Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain.
Intestinal alkaline phosphatase prevents metabolic syndrome in mice.
Title: Intestinal alkaline phosphatase prevents metabolic syndrome in mice.
These data suggest that IAP is a local immunomodulating factor, perhaps regulating LPS-toll-like receptor 4 (TLR4) interaction between commensal microflora and intestinal epithelium.
Title: A role for intestinal alkaline phosphatase in the maintenance of local gut immunity.
Intestinal alkaline phosphatase activity may have a role in mediating the accelerated fatty acid intake observed in Akp3 knockout mice fed a high-fat diet.
Title: A novel phosphatase upregulated in Akp3 knockout mice.
Results suggest that intestinal alkaline phosphatase participates in a rate-limiting step regulating fat absorption.
Title: Accelerated fat absorption in intestinal alkaline phosphatase knockout mice.
forced high-fat chow induced an 18% greater body weight gain, hepatic steatosis, and visceral fat accumulation in female Akp3(-/-) mice but not in female wild-type controls. there is 2X increase of lipid absorption in Akp3(-/-) male mice.
Title: Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Akp3 (e-PCR), detects polymorphism
- UniSTS:141064

PMC207564P1 (e-PCR)
- UniSTS:271949

PMC207564P2 (e-PCR)
- UniSTS:271950

D9Wox39 (e-PCR)
- UniSTS:518746

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
enables alkaline phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intestinal-type alkaline phosphatase

Names: intestinal alkaline phosphatase

NP_031458.2

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.