U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rab4a RAB4A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 19341, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rab4aprovided by MGI
    Official Full Name
    RAB4A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:105069
    See related
    Ensembl:ENSMUSG00000019478 AllianceGenome:MGI:105069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab4
    Summary
    Predicted to enable several functions, including ATPase binding activity; guanyl ribonucleotide binding activity; and ionotropic glutamate receptor binding activity. Involved in neurotransmitter receptor transport postsynaptic membrane to endosome and vesicle-mediated transport in synapse. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in endosome. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver and biliary system; and primitive endoderm. Orthologous to human RAB4A (RAB4A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 26.3), cerebellum adult (RPKM 22.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rab4a in Genome Data Viewer
    Location:
    8 E2; 8 72.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124532748..124562030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123805846..123835291)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732419C18 gene Neighboring gene predicted gene, 36188 Neighboring gene STARR-seq mESC enhancer starr_22987 Neighboring gene centriole, cilia and spindle associated protein Neighboring gene STARR-positive B cell enhancer ABC_E5049 Neighboring gene predicted gene 4342 Neighboring gene predicted gene 9901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in insulin-responsive compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-4A
    NP_033029.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009003.5NP_033029.2  ras-related protein Rab-4A

      See identical proteins and their annotated locations for NP_033029.2

      Status: VALIDATED

      Source sequence(s)
      AC147266, AEKQ02169250
      Consensus CDS
      CCDS52703.1
      UniProtKB/Swiss-Prot
      P56371, Q3TSQ6
      UniProtKB/TrEMBL
      Q3ULK1
      Related
      ENSMUSP00000113886.2, ENSMUST00000118535.9
      Conserved Domains (1) summary
      cd04113
      Location:14174
      Rab4; Rab GTPase family 4 (Rab4)

    RNA

    1. NR_188946.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147266, AEKQ02169250

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124532748..124562030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)