Il12b interleukin 12b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il12bprovided by MGI
Official Full Name: interleukin 12bprovided by MGI
Primary source: MGI:MGI:96540
See related: Ensembl:ENSMUSG00000004296 AllianceGenome:MGI:96540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p40; Il-12b; Il12p40; Il-12p40
Summary: This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]
Expression: Biased expression in thymus adult (RPKM 1.0), spleen adult (RPKM 0.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 25.94 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (44290890..44305504)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (44400063..44414677)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not gammadeltaT 17 cells, in TAC mice.
Title: IL-12p40 deletion reduces M1 macrophage polarization and alleviates cardiac remodeling via regulating Th17 cells differentiation, but not γδT 17 cells, in TAC mice.
Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells.
Title: Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells.
IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.
Title: IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice.
IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.
Title: IL-12p40 promotes secondary damage and functional impairment after spinal cord contusional injury.
Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model.
Title: Transcriptional changes in dendritic cells underlying allergen specific induced tolerance in a mouse model.
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Title: The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Role of p40(phox) in host defense against Citrobacter rodentium infection.
Title: Role of p40(phox) in host defense against Citrobacter rodentium infection.
Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction.
Title: Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.
Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.
Title: Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers.
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
Title: Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.

Submit: New GeneRIF Correction See all GeneRIFs (184)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC228408P3 (e-PCR)
- UniSTS:272156

Il12b (e-PCR), detects polymorphism
- UniSTS:463947

PMC162211P1 (e-PCR)
- UniSTS:271459

PMC355839P1 (e-PCR)
- UniSTS:273257

PMC355839P2 (e-PCR)
- UniSTS:273258

PMC355839P4 (e-PCR)
- UniSTS:273260

NoName (e-PCR)
- UniSTS:489073

PMC116546P3 (e-PCR)
- UniSTS:270316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytokine activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to cytokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
contributes_to growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 alpha subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-12 alpha subunit binding	ISO Inferred from Sequence Orthology more info
enables interleukin-23 receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-23 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 1 cell cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-12-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in response to UV-B	ISO Inferred from Sequence Orthology more info
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endosome lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-12 complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of interleukin-12 complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-23 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: CLMF p40; IL-12 p40 subunit; IL-12 subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin-12 p40 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303244.1 → NP_001290173.1 interleukin-12 subunit beta precursor

See identical proteins and their annotated locations for NP_001290173.1

Status: REVIEWED

Source sequence(s)

AL669944, BY154173, M86671

Consensus CDS

CCDS24563.1

UniProtKB/Swiss-Prot

P43432, Q9QUM1

UniProtKB/TrEMBL

Q3ZAX5

Related

ENSMUSP00000099860.4, ENSMUST00000102796.10

Conserved Domains (3) summary

smart00408
Location:42 → 90

IGc2; Immunoglobulin C-2 Type

smart00410
Location:42 → 91

IG_like; Immunoglobulin like

pfam10420
Location:123 → 214

IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

44290890..44305504

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008352.2: Suppressed sequence

Description

NM_008352.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.