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    Rlf rearranged L-myc fusion sequence [ Mus musculus (house mouse) ]

    Gene ID: 109263, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rlfprovided by MGI
    Official Full Name
    rearranged L-myc fusion sequenceprovided by MGI
    Primary source
    MGI:MGI:1924705
    See related
    Ensembl:ENSMUSG00000049878 AllianceGenome:MGI:1924705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MommeD8; 9230110M18Rik
    Summary
    Enables DNA binding activity. Acts upstream of or within negative regulation of heterochromatin formation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; liver; male reproductive system; spleen; and urinary system. Orthologous to human RLF (RLF zinc finger). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Rlf in Genome Data Viewer
    Location:
    4 D2.2; 4 56.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (121003080..121072318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (121145883..121215121, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit gamma, pseudogene 3 Neighboring gene predicted gene 12882 Neighboring gene STARR-positive B cell enhancer ABC_E8954 Neighboring gene STARR-seq mESC enhancer starr_11261 Neighboring gene predicted gene, 30102 Neighboring gene predicted gene, 40239 Neighboring gene STARR-seq mESC enhancer starr_11263 Neighboring gene STARR-seq mESC enhancer starr_11264 Neighboring gene predicted gene 12888

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346660.1NP_001333589.1  zinc finger protein Rlf

      Status: VALIDATED

      Source sequence(s)
      AL606927
      Consensus CDS
      CCDS84789.1
      UniProtKB/TrEMBL
      A2A7F4, E9Q532
      Related
      ENSMUSP00000050825.6, ENSMUST00000056635.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      121003080..121072318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319915.2XP_017175404.1  zinc finger protein Rlf isoform X1

      UniProtKB/TrEMBL
      E9Q532
      Conserved Domains (2) summary
      COG5236
      Location:426602
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_006502657.4XP_006502720.1  zinc finger protein Rlf isoform X1

      See identical proteins and their annotated locations for XP_006502720.1

      UniProtKB/TrEMBL
      E9Q532
      Conserved Domains (2) summary
      COG5236
      Location:426602
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006502658.2XP_006502721.1  zinc finger protein Rlf isoform X1

      See identical proteins and their annotated locations for XP_006502721.1

      UniProtKB/TrEMBL
      E9Q532
      Conserved Domains (2) summary
      COG5236
      Location:426602
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_036163579.1XP_036019472.1  zinc finger protein Rlf isoform X1

      UniProtKB/TrEMBL
      E9Q532
      Conserved Domains (2) summary
      COG5236
      Location:426602
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_030253080.2XP_030108940.1  zinc finger protein Rlf isoform X1

      UniProtKB/TrEMBL
      E9Q532
      Conserved Domains (2) summary
      COG5236
      Location:426602
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:496516
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081013.1: Suppressed sequence

      Description
      NM_001081013.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.