DUOX1 dual oxidase 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DUOX1provided by VGNC
Official Full Name: dual oxidase 1provided by VGNC
Primary source: VGNC:VGNC:40120
See related: Ensembl:ENSCAFG00845030684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: THOX1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 30

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	30	NC_051834.1 (11692796..11724747)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	30	NC_006612.4 (11612190..11644063)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	30	NC_049251.1 (11841362..11873559)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	30	NC_049290.1 (11599266..11631208)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	30	NC_049771.1 (11721544..11753719)

Chromosome 30 - NC_051834.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual oxidase 1

Names: NADPH thyroid oxidase 1; thyroid oxidase 1

NP_001003122.1

EC 1.6.3.1

XP_038297650.1

EC 1.6.3.1

XP_038297651.1

EC 1.6.3.1

XP_038297652.1

EC 1.6.3.1

XP_038297653.1

EC 1.6.3.1

XP_038297655.1

EC 1.6.3.1

XP_038297656.1

EC 1.6.3.1

XP_038297657.1

EC 1.6.3.1

XP_038297658.1

EC 1.6.3.1

XP_038297659.1

EC 1.6.3.1

XP_038297660.1

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003122.2 → NP_001003122.1 dual oxidase 1 precursor

See identical proteins and their annotated locations for NP_001003122.1

Status: PROVISIONAL

Source sequence(s)

AF230497

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Related

ENSCAFP00845042818.1, ENSCAFT00845054476.1

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051834.1 Reference ROS_Cfam_1.0

Range

11692796..11724747

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038441724.1 → XP_038297652.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441722.1 → XP_038297650.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441732.1 → XP_038297660.1 dual oxidase 1 isoform X2

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1265 → 1539

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1077 → 1400

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441727.1 → XP_038297655.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441723.1 → XP_038297651.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441729.1 → XP_038297657.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441728.1 → XP_038297656.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441730.1 → XP_038297658.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441725.1 → XP_038297653.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_038441731.1 → XP_038297659.1 dual oxidase 1 isoform X1

UniProtKB/Swiss-Prot

Q9MZF4

UniProtKB/TrEMBL

A0A8C0N3I4

Conserved Domains (5) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

COG5126
Location:750 → 920

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...